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Titolo:
Interleukin 6 and C-reactive protein levels in patients with acute allergic reactions: an emergency department-based study
Autore:
Lin, RY; Trivino, MR; Curry, A; Pesola, GR; Knight, RJ; Lee, HS; Bakalchuk, L; Tenenbaum, C; Westfal, RE;
Indirizzi:
St Vincents Hosp, Dept Med, New York, NY 10011 USA St Vincents Hosp New York NY USA 10011 , Dept Med, New York, NY 10011 USA St Vincents Hosp, Dept Emergency Med, New York, NY 10011 USA St Vincents Hosp New York NY USA 10011 rgency Med, New York, NY 10011 USA New York Med Coll, Med Ctr, New York, NY USA New York Med Coll New York NY USA rk Med Coll, Med Ctr, New York, NY USA
Titolo Testata:
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
fascicolo: 5, volume: 87, anno: 2001,
pagine: 412 - 416
SICI:
1081-1206(200111)87:5<412:I6ACPL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA; IL-6; ARTHRITIS; HISTAMINE; TRYPTASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, RY St Vincents Hosp, Dept Med, 153 W 11th St, New York, NY 10011 USA St Vincents Hosp 153 W 11th St New York NY USA 10011 NY 10011 USA
Citazione:
R.Y. Lin et al., "Interleukin 6 and C-reactive protein levels in patients with acute allergic reactions: an emergency department-based study", ANN ALLER A, 87(5), 2001, pp. 412-416

Abstract

Background: Elevations of interleukin 6 (IL-6) have been described in drug-induced anaphylaxis. Although IL-6 is well known to stimulate an acute phase response, profiling acute phase protein levels, such as C-reactive protein (CRP), has, to our knowledge, never been performed in patients with acute allergic reactions. Objective: To examine the pattern of IL-6 and CRP levels in patients with acute allergic reactions and to relate these to relevant clinical and laboratory parameters. Methods: Plasma CRP and serum IL-6 levels were determined in 85 adult emergency department patients. These patients had been previously studied with questionnaires, physical examinations, and histamine/tryptase levels. Clinical and historical features were related to CRP and IL-6 levels. CRP and IL-6 levels were also examined for relationships with histamine and tryptase levels. Results: CRP and IL-6 levels were significantly correlated with one another in the study patients (Spearman rho = 0.36, P = 0.0008). Similar to histamine levels, IL-6 levels were significantly correlated with the extent of erythema manifested by the study patients. The extent of erythema was independently predicted by both IL-6 and histamine levels. Histamine levels were negatively correlated with CRP levels (Spearman rho = -0.32, P = 0.003). Unlike histamine levels, IL-6 and CRP did not show significant relationships with the extent or presence of urticaria/angioedema or the presence of wheezing. IL-6 levels were correlated with the duration of symptoms before serologic sampling. An inverse correlation was observed between IL-6 levels andmean arterial blood pressure. Multivariate modeling showed significant independent effects from mean arterial pressure, duration of symptoms, erythema extent, and age in predicting IL-6 levels. Tryptase levels were higher inpatients whose IL-6 levels were > 20 pg/mL. Conclusions: CRP and IL-6 levels are not simple surrogate markers for histamine or tryptase release by mast cells or basophils in acute allergic reactions. Increasing IL-6 levels relate to greater erythema extent, lower meanarterial blood pressure, and a longer duration of symptoms. It would be interesting to speculate that CRP and IL-6 increases characterize a late-phase response in immediate hypersensitivity reactions. In this perspective, the inverse relationship between CRP and histamine levels could be explained. As histamine levels are waning, CRP levels are increasing. Timed studies for histamine and CRP/IL-6 levels in allergic reactions are necessary to confirm this hypothesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 10:44:52