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Titolo:
Efficient synthesis of pyrenylalanine
Autore:
Szymanska, A; Wiczk, W; Lankiewicz, L;
Indirizzi:
Univ Gdansk, Fac Chem, PL-80952 Gdansk, Poland Univ Gdansk Gdansk PolandPL-80952 sk, Fac Chem, PL-80952 Gdansk, Poland
Titolo Testata:
AMINO ACIDS
fascicolo: 3, volume: 21, anno: 2001,
pagine: 265 - 270
SICI:
0939-4451(2001)21:3<265:ESOP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIMENSIONAL AROMATIC CRYSTALS; ENERGY-TRANSFER; FLUORESCENCE; POLY(L-1-PYRENYLALANINE); TRYPTOPHAN; BINDING;
Keywords:
amino acids; asymmetric synthesis; pyrenylalanine; fluorescent compounds;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lankiewicz, L Univ Gdansk, Fac Chem, Sobieskiego 18, PL-80952 Gdansk, Poland Univ Gdansk Sobieskiego 18 Gdansk Poland PL-80952 k, Poland
Citazione:
A. Szymanska et al., "Efficient synthesis of pyrenylalanine", AMINO ACIDS, 21(3), 2001, pp. 265-270

Abstract

An efficient synthesis Of L-3-(1'-pyrenyl)alanine (Pya), a highly fluorescent amino acid, is described. The amino acid was obtained by the classical asymmetric hydrogenation of chiral 1-acetyl-3-pyrenemethylidene-6-methyl-piperazine-2,5-dione. In the proposed improved procedure mild conditions of the synthesis were applied and the final product - N-tert-butoxycarbonyl-pyrenylalanine - was obtained in good yield. Pyrenylalanine, due to its interesting photophysical properties, can be applied as a fluorescent probe in numerous biochemical and conformational studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:21:33