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Titolo:
Cold-induced rhinitis in skiers - Clinical aspects and treatment with ipratropium bromide nasal spray: A randomized controlled trial
Autore:
Bonadonna, P; Senna, G; Zanon, P; Cocco, G; Dorizzi, R; Gani, F; Landi, M; Restuccia, M; Feliciello, A; Passalacqua, G;
Indirizzi:
Verona Gen Hosp, Allergy Unit, Verona, Italy Verona Gen Hosp Verona Italy rona Gen Hosp, Allergy Unit, Verona, Italy
Titolo Testata:
AMERICAN JOURNAL OF RHINOLOGY
fascicolo: 5, volume: 15, anno: 2001,
pagine: 297 - 301
SICI:
1050-6586(200109/10)15:5<297:CRIS-C>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-COUNTRY SKIERS; DRY AIR; INFLAMMATORY MEDIATORS; VASOMOTOR RHINITIS; RHINORRHEA; INHALATION; MUCOSA; SECRETION; HISTAMINE; CHALLENGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Passalacqua, G Univ Genoa, DIMI, Pad Maragliano,Lgo R Benzi 10, I-16132 Genoa, Italy Univ Genoa Pad Maragliano,Lgo R Benzi 10 Genoa Italy I-16132
Citazione:
P. Bonadonna et al., "Cold-induced rhinitis in skiers - Clinical aspects and treatment with ipratropium bromide nasal spray: A randomized controlled trial", AM J RHINOL, 15(5), 2001, pp. 297-301

Abstract

Cold-induced rhinitis (CIR) is common among skiers and is perceived as a troublesome disease. We studied the clinical characteristics of CIR in a population of skiers and we evaluated the effectiveness of ipratrophan bromidenasal spray (IBNS) in relieving symptoms in a double-blind placebo-controlled fashion. By means of specific questionnaires, we evaluated 144 subjects(69% men; mean age, 42.2 years). The prevalence of CIR was 48.6% and the distinctive symptom was rhinorrhea (96%), often severe. The prevalence of atopy was higher in the CIR patients (chi (2); p = 0.004). Twenty-eight CIR subjects participated in a double-blind placebo-controlled cross-over trial for evaluating the effectiveness of IBNS (80 mug twice per day [b.i.d.]). The severity of symptoms was assessed by a visual analog scale, and the number of cleaning tissues used also was evaluated. The actively treated group showed a significant improvement of rhinorrhea (p = 0.0007) and a reductionin the number of cleaning tissues used (p = 0.0023). Only four mild local side effects were reported. We conclude that IBNS could be regarded as an optimal therapeutic option for treating CIR symptoms in skiers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:31:34