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Titolo:
Neurotrophins and neurotrophin receptors in human lung cancer
Autore:
Ricci, A; Greco, S; Mariotta, S; Felici, L; Bronzetti, E; Cavazzana, A; Cardillo, G; Amenta, F; Bisetti, A; Barbolini, G;
Indirizzi:
Univ Roma La Sapienza, Dipartimento Sci Cardiovasc & Resp, I-00185 Rome, Italy Univ Roma La Sapienza Rome Italy I-00185 asc & Resp, I-00185 Rome, Italy Osped Carlo Forlanini, Serv Anat Patol, I-00151 Rome, Italy Osped Carlo Forlanini Rome Italy I-00151 Anat Patol, I-00151 Rome, Italy Osped Carlo Forlanini, Unita Operat Chirurg Torac, I-00151 Rome, Italy Osped Carlo Forlanini Rome Italy I-00151 rurg Torac, I-00151 Rome, Italy Univ Camerino, Dipartimento Sci Farmacol & Med Sperimentale, I-62032 Camerino, Italy Univ Camerino Camerino Italy I-62032 erimentale, I-62032 Camerino, Italy Univ Modena, Ist Anat Patol, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 , Ist Anat Patol, I-41100 Modena, Italy
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 439 - 446
SICI:
1044-1549(200110)25:4<439:NANRIH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; HUMAN PROSTATE; HIGH-AFFINITY; CELL-LINES; IMMUNOHISTOCHEMICAL ANALYSIS; MELANOMA-CELLS; IN-VITRO; EXPRESSION; BINDING; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ricci, A Osped Carlo Forlanini, Dipartimento Sci Cardiovasc & Resp, PiazzaC Forlanini 1, I-00151 Rome, Italy Osped Carlo Forlanini Piazza C Forlanini 1 Rome Italy I-00151 ly
Citazione:
A. Ricci et al., "Neurotrophins and neurotrophin receptors in human lung cancer", AM J RESP C, 25(4), 2001, pp. 439-446

Abstract

The expression of neurotrophins (NTs) and related high- and low-affinity receptors was studied in surgical samples of histologically diagnosed human tumors of the lower respiratory tract. The experiment was conducted with 30non-small cell lung cancer specimens and in eight small cell lung cancer specimens by Western biot analysis and immunohistochemistry to assess expression and distribution of NT and NT receptor proteins in tissues examined. Immunoblots of homogenates from human tumors displayed binding of anti-nervegrowth factor (NGF), brain-derived neurotrophic factor (BDNF), and NT-3 antibodies as well as of anti-tyrosine-specific protein kinase (Trk) A, TrkB,and TrkC receptor antibodies, with similar migration characteristics than those displayed by human P-NGF and proteins from rat brain. A specific immunoreactivity for NTs and NT receptors was demonstrated in vessel wails, stromal fibroblasts, immune cells, and sometimes within neoplastic cell bodies. Approximately 33% of bronchioloalveolar carcinomas exhibited a strong membrane NGF and TrkA immunoreactivity, whereas 46% adenocarcinomas expressed an intense TrkA immunoreactivity but a weak immunostaining for NGF within tumor cells. Moreover, squamous cell carcinomas developed an intense TrkA immunoreactivity only within stroma surrounding neoplastic cells. A faint BDNF an Tr immunoreactivity was documented in adenocarcinomas, squamous cell carcinomas, and small cell lung cancers. NT-3 and its corresponding TrkC receptor were found in a small number of squamous cell carcinomas within large-size tumor cells. No expression of low-affinity p75 receptor protein was found in tumor cells. The detection of NTs and NT receptor proteins in tumors of the lower respiratory tract suggests that NTs may be involved in controlling growth and differentiation of human lung cancer and/or influencing tumor behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:37:41