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Titolo:
NMDA RECEPTOR COMPLEX BLOCKADE BY ORAL-ADMINISTRATION OF MAGNESIUM - COMPARISON WITH MK-801
Autore:
DECOLLOGNE S; TOMAS A; LECERF C; ADAMOWICZ E; SEMAN M;
Indirizzi:
UNIV PARIS 07,HALL BIOTECHNOL,TOUR 54,CP7124,2 PL JUSSIEU F-75251 PARIS 05 FRANCE UNIV PARIS 07,HALL BIOTECHNOL F-75251 PARIS 05 FRANCE IRPC F-92350 LE PLESSIS ROBINS FRANCE LABS MAYOLY SPINDLER F-78401 CHATOU FRANCE
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 58, anno: 1997,
pagine: 261 - 268
SICI:
0091-3057(1997)58:1<261:NRCBBO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; YOHIMBINE-INDUCED SEIZURES; ANTIDEPRESSANT DRUGS; ANTAGONISTS; INHIBITION; CALCIUM; BRAIN; MODEL; HYPOMAGNESEMIA; PHENCYCLIDINE;
Keywords:
MAGNESIUM ORGANIC SALTS; MK-801; MICE; NM DA ANTAGONISTS; FORCED SWIMMING TEST; ANTICONVULSANT; ABSORPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
S. Decollogne et al., "NMDA RECEPTOR COMPLEX BLOCKADE BY ORAL-ADMINISTRATION OF MAGNESIUM - COMPARISON WITH MK-801", Pharmacology, biochemistry and behavior, 58(1), 1997, pp. 261-268

Abstract

The ion channel of the N-methyl-D-aspartate (NMDA) receptor complex is subject to a voltage-dependent regulation by Mg2+ cations. Under physiological conditions, this channel is supposed to be blocked by a high concentration of magnesium in extracellular fluids. A single dose ofmagnesium organic salts (i.e., aspartate, pyroglutamate, and lactate)given orally to normal mice rapidly increases the plasma Mg2+ level and reveals a significant dose-dependent antagonist effect of magnesiumon the latency of NMDA-induced convulsions; this effect is similar tothat seen after administration of the dizocilpine (MK-801) channel blocker. An anticonvulsant effect of Mg2+ treatment is also observed with strychnine-induced convulsions but not with bicuculline-, picrotoxin-, or pentylenetetrazol-induced convulsions. In the forced swimming test, Mg2+ salts reduce the immobility time in a way similar to imipramine and thus resemble the antidepressant-like activity of MK-801. This activity is masked at high doses of magnesium by a myorelaxant effect that is comparable to MK-801-induced ataxia. Potentiation of yohimbinefatal toxicity is another test commonly used to evaluate putative antidepressant drugs. Administration of Mg2+ salts, like administration of imipramine, strongly potentiates yohimbine lethality, in contrast toMK-801, which is only poorly active in this test. Neither Mg2+ nor MK-801 treatment can prevent reserpine-induced hypothermia. These data demonstrate that oral administration of magnesium to normal animals canantagonize NMDA-mediated responses and lead to antidepressant-like effects that are comparable to those of MK-801. This important regulatory role of Mg2+ in the central nervous system needs further investigation to evaluate the potential therapeutic advantages of magnesium supplementation in psychiatric disorders. (C) 1997 Elsevier Science Inc.

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Documento generato il 02/12/20 alle ore 05:06:42