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Titolo:
Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron
Autore:
Wang, T; Hropot, M; Aronson, PS; Giebisch, G;
Indirizzi:
Dept Cellular & Mol Physiol, D-65926 Frankfurt, Germany Dept Cellular & Mol Physiol Frankfurt Germany D-65926 Frankfurt, Germany Aventis Pharma Deutschland, D-65926 Frankfurt, Germany Aventis Pharma Deutschland Frankfurt Germany D-65926 Frankfurt, Germany Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 pt Internal Med, New Haven, CT 06520 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: F1117 - F1122
SICI:
0363-6127(200112)281:6<F1117:RONIIM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL CONVOLUTED TUBULE; NA+/H+ EXCHANGER ISOFORM; THICK ASCENDING LIMB; RENAL BRUSH-BORDER; MOLECULAR-CLONING; APICAL MEMBRANE; H+ EXCHANGER; CDNA CLONING; RAT; TRANSPORT;
Keywords:
sodium/hydrogen exchange; acidification; proximal; loop of Henle; distal convoluted tubule; sodium/hydrogen exchanger;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, T Yale Univ, Sch Med, Dept Cellular & Mol Physiol, 333 Cedar St,POB 208026, New Haven, CT 06520 USA Yale Univ 333 Cedar St,POB 208026 New HavenCT USA 06520 06520 USA
Citazione:
T. Wang et al., "Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron", AM J P-REN, 281(6), 2001, pp. F1117-F1122

Abstract

This study assessed the functional role of Na+ /H+ exchanger (NHE) isoforms NHE3 and NHE2 in the proximal tubule, loop of Henle, and distal convoluted tubule of the rat kidney by comparing sensitivity of transport to inhibition by Hoe-694 (an agent known to inhibit NHE2 but not NHE3) and S-3226 (anagent with much higher affinity for NHE3 than NHE2). Rates of transport offluid (J(v)) and HCO3- (J(HCO3)) were studied by in situ microperfusion. In the proximal tubule, addition of ethylisopropylamiloride or S-3226 significantly reduced J(v) and J(HCO3), but addition of Hoe-694 caused no significant inhibition. In the loop of Henle, J(HCO3) was also inhibited by S-3226and not by Hoe-694, although much higher concentrations of S-3226 were required than what was necessary to inhibit transport in the proximal tubule. In contrast, in the distal convoluted tubule, J(HCO3) was inhibited by Hoe-694 but not by S-3226. These results are consistent with the conclusion that NHE2 rather than NHE3 is the predominant isoform responsible for apical membrane Na+/H+ exchange in the distal convoluted tubule, whereas NHE3 is the predominant apical isoform in the proximal tubule and possibly also in the loop of Henle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:28:27