Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hypothalamic dopaminergic receptor expressions in anorexia of tumor-bearing rats
Autore:
Sato, T; Meguid, MM; Fetissov, SO; Chen, C; Zhang, LH;
Indirizzi:
SUNY Upstate Med Univ, Univ Hosp, Dept Surg, Surg Metab & Nutr Lab,Neurosci Program, Syracuse, NY 13210 USA SUNY Upstate Med Univ Syracuse NY USA 13210 ogram, Syracuse, NY 13210 USA Syracuse Univ, Dept Quantitat Methods, Syracuse, NY 13244 USA Syracuse Univ Syracuse NY USA 13244 titat Methods, Syracuse, NY 13244 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: R1907 - R1916
SICI:
0363-6119(200112)281:6<R1907:HDREIA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAUDATE-NUCLEUS NEURONS; OBESE ZUCKER RATS; MESSENGER-RNA; FOOD-INTAKE; PHARMACOLOGICAL CHARACTERIZATION; LATERAL HYPOTHALAMUS; SEROTONIN RECEPTORS; ADENYLATE-CYCLASE; FEEDING-BEHAVIOR; BINDING-SITES;
Keywords:
messenger RNA; dopaminergic receptor antagonist; sulpiride; SCH-23390; meal size; meal number;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Meguid, MM SUNY Upstate Med Univ, Univ Hosp, Dept Surg, Surg Metab & Nutr Lab,Neurosci Program, 750 E Adams St, Syracuse, NY 13210 USA SUNY Upstate Med Univ 750 E Adams St Syracuse NY USA 13210 USA
Citazione:
T. Sato et al., "Hypothalamic dopaminergic receptor expressions in anorexia of tumor-bearing rats", AM J P-REG, 281(6), 2001, pp. R1907-R1916

Abstract

Our past microdialysis studies in ventromedial hypothalamic nucleus (VMN) and lateral hypothalamic area (LHA) of changes in dopamine concentrations in response to changes in food intake [characterized as feeding pattern (changes in meal number and size)] in anorexia of cancer show abnormal presynaptic dopaminergic neurotransmission. To determine postsynaptic receptor status, studies were done in tumor-bearing (TB) and non-tumor-bearing (NTB) free-feeding control rats while continuously measuring their food intake via arat eater meter. When TB rats developed anorexia, TB and control rats werekilled, and postsynaptic D-1- and D-2-receptor mRNA expression in LHA and VMN were measured via RT-PCR. At anorexia, food intake decreased initially by a decrease in meal number, whereas a concurrent increase in meal size occurred for 24 h in an attempt to maintain food intake constant. Then meal size also decreased. At this time, D-1- and D-2-receptor mRNA expressions inLHA and VMN of TB vs. controls were significantly upregulated. Verification of D-1- or D-2-receptor changes to changes in meal number and size at anorexia was made by injection of intra-VMN or -LHA dopaminergic receptor antagonists. Intra-VMN D-1-receptor antagonist (SCH-23390) in TB rats decreasedfood intake mainly via a decrease in meal size. Intra-VMN D-2-receptor antagonist (sulpiride) in TB rats increased food intake via an increase in meal number and in NTB free-feeding rats by an increase in meal size. Intra-LHA D-1-receptor antagonist in TB rats had no effect on food intake or feeding pattern. Intra-LHA D-2-receptor antagonist in TB and in NTB free-feeding rats increased food intake via an increase in meal number. Our data provideevidence that postsynaptic dopaminergic receptor subtypes in the hypothalamus are involved in the regulation of meal size, meal number, and thus foodintake in anorectic TB rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:01:09