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Titolo:
GLP-2 has differential effects on small intestine growth and function in fetal and neonatal pigs
Autore:
Petersen, YM; Burrin, DG; Sangild, PT;
Indirizzi:
Royal Vet & Agr Univ, Div Anim Nutr, DK-1870 Copenhagen, Denmark Royal Vet& Agr Univ Copenhagen Denmark DK-1870 1870 Copenhagen, Denmark Baylor Coll Med, Dept Pediat, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Nutr Res Ctr, Houston, TX 77030 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: R1986 - R1993
SICI:
0363-6119(200112)281:6<R1986:GHDEOS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCAGON-LIKE PEPTIDE-2; IN-VIVO; RECEPTOR; PROLIFERATION; EXPRESSION; INDUCTION; HUMANS;
Keywords:
birth; receptor; mRNA; peptidase; maltase; proglucagon; development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Petersen, YM Royal Vet & Agr Univ, Div Anim Nutr, 3 Gronnegardsvej, DK-1870 Copenhagen,Denmark Royal Vet & Agr Univ 3 Gronnegardsvej Copenhagen Denmark DK-1870
Citazione:
Y.M. Petersen et al., "GLP-2 has differential effects on small intestine growth and function in fetal and neonatal pigs", AM J P-REG, 281(6), 2001, pp. R1986-R1993

Abstract

Glucagon-like peptide-2 (GLP-2) is a potent intestinotropic factor in neonatal and adult animals. However, the GLP-2 responsiveness of the fetal intestine has not been established. To determine how stage of development affects the responsiveness to GLP-2, we examined GLP-2 receptor (GLP-2R) expression, gut morphology, and brush-border enzyme mRNA and activities in late-gestation fetal (n = 7) and parenterally fed neonatal (n = 7) piglets given GLP-2 (12.5 nmol/kg) twice daily for 6 days. The GLP-2R was expressed in thefetal and neonatal gastrointestinal tract. The biologically active GLP2-(1-33) was undetectable (<5 pmol/l) in plasma of 98-day-gestation fetuses butincreased significantly toward full term (115 days, 11 +/- 1 pmol/l) and in neonates fed by total parenteral nutrition (23 +/- 5 pmol/l). Exogenous GLP-2 had no effect on gut growth in fetuses but increased intestinal weightand villus height in neonates (P < 0.05). Crypt cell proliferation and theenzymes sucrase-isomaltase, lactase-phloridzin hydrolase, aminopeptidase A, and dipeptidyl peptidase IV were unchanged by GLP-2 in both groups. Aminopeptidase N mRNA and activity were increased in fetuses, while maltase mRNAand activity were increased in neonates. In conclusion, exogenous GLP-2 had different effects on small intestine growth and function in fetuses and neonates. This may be related to the normal developmental changes in intestine growth and function and to a maturation of the GLP-2R signaling pathwaysaround the time of birth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 08:41:15