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Titolo:
Developmental changes in intracellular pH regulation in medullary neurons of the rat
Autore:
Nottingham, S; Leiter, JC; Wages, P; Buhay, S; Erlichman, JS;
Indirizzi:
St Lawrence Univ, Dept Biol, Canton, NY 13617 USA St Lawrence Univ CantonNY USA 13617 niv, Dept Biol, Canton, NY 13617 USA Allegheny Coll, Dept Biol, Meadville, PA 16335 USA Allegheny Coll Meadville PA USA 16335 Dept Biol, Meadville, PA 16335 USA Dartmouth Coll, Sch Med, Dept Physiol, Lebanon, NH 03756 USA Dartmouth Coll Lebanon NH USA 03756 , Dept Physiol, Lebanon, NH 03756 USA Dartmouth Coll, Sch Med, Dept Med, Lebanon, NH 03756 USA Dartmouth Coll Lebanon NH USA 03756 Med, Dept Med, Lebanon, NH 03756 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: R1940 - R1951
SICI:
0363-6119(200112)281:6<R1940:DCIIPR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARII; CENTRAL-NERVOUS-SYSTEM; NA+-H+ EXCHANGER; BRAIN-STEM; HIPPOCAMPAL-NEURONS; SPINAL-CORD; IN-VITRO; RETROTRAPEZOID NUCLEUS; VENTILATORY RESPONSES; POSTNATAL-DEVELOPMENT;
Keywords:
chemoreceptor; brain slice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Erlichman, JS St Lawrence Univ, Dept Biol, Canton, NY 13617 USA St Lawrence Univ Canton NY USA 13617 , Canton, NY 13617 USA
Citazione:
S. Nottingham et al., "Developmental changes in intracellular pH regulation in medullary neurons of the rat", AM J P-REG, 281(6), 2001, pp. R1940-R1951

Abstract

We examined intracellular pH (pH(i)) regulation in the retrotrapezoid nucleus (RTN), a CO2-sensitive site, and the hypoglossal nucleus, a nonchemosensitive site, during development (postnatal days 2-18) in rats. Respiratory acidosis [10% CO2, extracellular pH (pH(o)) 7.18] caused acidification without pH(i) recovery in the RTN at all ages. In the hypoglossal nucleus, pH(i) recovered in young animals, but as animal age increased, the slope of pH(i) recovery diminished. In animals older than postnatal day 11, the pH(i) responses to hypercapnia were identical in the hypoglossal nucleus and the RTN, but hypoglossal nucleus and RTN neurons could regulate pH(i) during intracellular acidification at constant pHo at all ages. Recovery of pH(i) from acidification in the RTN depended on extracellular Na+ and was inhibited by amiloride but was unaffected by DIDS, suggesting a role for Na+/H+ exchange. Hence, pH(i) regulation during acidosis is more effective in the hypoglossal nucleus in younger animals, possibly as a requirement of development, but in older juvenile animals (older than postnatal day 11), pH(i) regulation is relatively poor in chemosensitive (RTN) and nonchemosensitive nuclei (hypoglossal nucleus).

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Documento generato il 25/01/20 alle ore 10:11:38