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Titolo:
Functional effects of protease-activated receptor-2 stimulation on human airway smooth muscle
Autore:
Chambers, LS; Black, JL; Poronnik, P; Johnson, PRA;
Indirizzi:
Univ Sydney, Dept Pharmacol, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 rmacol, Sydney, NSW 2006, Australia Univ Sydney, Dept Physiol, Sydney, NSW 2006, Australia Univ Sydney SydneyNSW Australia 2006 hysiol, Sydney, NSW 2006, Australia Univ Sydney, Kolling Inst, Sydney, NSW 2006, Australia Univ Sydney SydneyNSW Australia 2006 g Inst, Sydney, NSW 2006, Australia
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: L1369 - L1378
SICI:
1040-0605(200112)281:6<L1369:FEOPRS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAST-CELL TRYPTASE; THROMBIN RECEPTOR; MOLECULAR-CLONING; EPITHELIAL-CELLS; ISOLATED BRONCHI; MITOGEN; EXPRESSION; HISTAMINE; GROWTH; HYPERRESPONSIVENESS;
Keywords:
tryptase; proliferation; contraction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Chambers, LS Univ Sydney, Dept Pharmacol, Sydney, NSW 2006, Australia UnivSydney Sydney NSW Australia 2006 y, NSW 2006, Australia
Citazione:
L.S. Chambers et al., "Functional effects of protease-activated receptor-2 stimulation on human airway smooth muscle", AM J P-LUNG, 281(6), 2001, pp. L1369-L1378

Abstract

The protease-activated receptor (PAR)-2 is present on the smooth muscle and epithelium of human airways and can be activated by mast cell tryptase, trypsin, or the PAR-2 activating peptide (AP). Trypsin and the PAR-2 AP induced contractions in human isolated airways, and these contractions were potentiated in the presence of the cyclooxygenase (COX) inhibitor indomethacin. Trypsin also increased the contractions to histamine in airways from sensitized (allergic) patients but not from nonsensitized (nonallergic) patients. Tryptase purified from human lung, skin and lung recombinant beta -tryptases, trypsin, and the PAR-2 AP all increased DNA synthesis in human airwaysmooth muscle (HASM) cells. Activation of PAR-2 by tryptase, trypsin, and the PAR-2 AP did not induce PGE(2) release from HASM cells. Trypsin and thePAR-2 AP increased the levels of intracellular calcium in HASM cells, withdesensitization evident after treatment with either agonist. In conclusion, activation of PAR-2 can induce contractions of human airways, potentiate contractions to histamine, and induce proliferation and therefore may contribute to airway diseases such as asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 12:05:10