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Titolo:
Rapid alveolar liquid removal by a novel convective mechanism
Autore:
Wang, PM; Ashino, Y; Ichimura, H; Bhattacharya, J;
Indirizzi:
Columbia Univ, St Lukes Roosevelt Hosp Ctr, New York, NY 10019 USA Columbia Univ New York NY USA 10019 velt Hosp Ctr, New York, NY 10019 USA Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10019 USA Columbia Univ Coll Phys & Surg New York NY USA 10019 w York, NY 10019 USA Columbia Univ Coll Phys & Surg, Dept Physiol & Cellular Biophys, New York,NY 10019 USA Columbia Univ Coll Phys & Surg New York NY USA 10019 ew York,NY 10019 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: L1327 - L1334
SICI:
1040-0605(200112)281:6<L1327:RALRBA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACTANT RELEASE; II CELLS; LUNG; EXOCYTOSIS; SECRETION; CALCIUM;
Keywords:
surfactant; pulmonary edema; cell calcium; Laplace equation; inflation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Bhattacharya, J Columbia Univ, St Lukes Roosevelt Hosp Ctr, 1000 10th Ave,New York, NY 10019 USA Columbia Univ 1000 10th Ave New York NY USA 10019 0019 USA
Citazione:
P.M. Wang et al., "Rapid alveolar liquid removal by a novel convective mechanism", AM J P-LUNG, 281(6), 2001, pp. L1327-L1334

Abstract

Although alveoli clear liquid by active transport, the presence of surface-active material on the alveolar surface suggests that convective mechanisms for rapid liquid removal may exist. To determine such mechanisms, we heldthe isolated blood-perfused rat lung at a constant alveolar pressure (PA). Under videomicroscopy, we micropunctured a single alveolus to infuse saline or Ringer solution in similar to 10 adjacent alveoli. Infused alveoli were lost from view. However, as the infused liquid cleared, the alveoli reappeared and their diameters could be quantified. Hence the time-dependent determination of alveolar diameter provided a means for quantifying the time to complete liquid removal (C-t) in single alveoli. All determinations were obtained at an PA of 5 cmH(2)O. C-t, which related inversely to alveolar diameter, averaged 4.5 s in alveoli with the fastest liquid removal. Injections of dye-stained liquid revealed that the liquid flowed from the injected alveoli to adjacent air-filled alveoli. Lung hyperinflations instituted by cycling PA between 5 and 15 cmH(2)O decreased C-t by 50%. Chelation of intracellular Ca2+ prolonged C-t and abolished the inflation-induced enhancement of liquid removal. We conclude that when liquid is injected in a few alveoli, it rapidly flows to adjacent air-filled alveoli. The removal mechanisms are dependent on alveolar size, inflation, and intracellular Ca2+. We speculate that removal of liquid from the alveolar surface is determined by the curvature and surface-active properties of the air-liquid interface.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:38:41