Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Arteriogenesis and angiogenesis in rat ischemic hindlimb: role of nitric oxide
Autore:
Lloyd, PG; Yang, HT; Terjung, RL;
Indirizzi:
Univ Missouri, Coll Vet Med, Dept Biomed Sci, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 pt Biomed Sci, Columbia, MO 65211 USA Univ Missouri, Coll Med, Dept Physiol, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Physiol, Columbia, MO 65211 USA Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 ovasc Res Ctr, Columbia, MO 65211 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: H2528 - H2538
SICI:
0363-6135(200112)281:6<H2528:AAAIRI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; PERIPHERAL ARTERIAL INSUFFICIENCY; COLLATERAL BLOOD-FLOW; FEMORAL-ARTERY; SKELETAL-MUSCLE; CELL MIGRATION; SYNTHASE INHIBITION; L-ARGININE; EXERCISE; ACTIVATION;
Keywords:
N-omega-nitro-L-arginine methyl ester; exercise training; capillaries; arterioles; nitric oxide synthase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Terjung, RL Univ Missouri, Coll Vet Med, Dept Biomed Sci, E102 Vet Med Bldg, Columbia,MO 65211 USA Univ Missouri E102 Vet Med Bldg Columbia MO USA 65211 5211 USA
Citazione:
P.G. Lloyd et al., "Arteriogenesis and angiogenesis in rat ischemic hindlimb: role of nitric oxide", AM J P-HEAR, 281(6), 2001, pp. H2528-H2538

Abstract

Nitric oxide (NO) has been implicated in both collateral expansion (arteriogenesis) and capillary growth (angiogenesis). Exercise training increases collateral-dependent blood flow to tissues at risk of ischemia and enhancescapillarity in active skeletal muscle. Exercise also acutely elevates NO. Thus we assessed the role of NO in training-induced arteriogenesis and angiogenesis. These studies utilized a rat model of peripheral vascular disease(bilateral femoral artery ligation). Untreated rats (control) and rats treated with the NO synthase inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME; 65-70 mg.kg(-1).day(-1), via drinking water) were divided into sedentary or exercise-trained subgroups. After similar to3 wk, L-NAME treatmenthad elevated preexercise mean arterial pressure similar to 39-58%, confirming NO synthesis inhibition. The training program (treadmill exercise twiceper day, 20-25 m/min, 15% grade, similar to 18 days) increased collateral-dependent blood flow to the distal hindlimb, with the greatest increase (similar to 59%) in the calf (P < 0.001). This increase was inhibited by L-NAME. In contrast, the training-induced increase in muscle capillarity was notblocked by L-NAME. Thus arteriogenesis and angiogenesis appear to differ in their requirement for NO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 09:31:16