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Titolo:
Interleukin-1 beta alters brown adipose tissue but not renal sympathetic nerve responses to hypothermia
Autore:
Kenney, MJ; Blecha, F; Morgan, DA; Fels, RJ;
Indirizzi:
Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA Kansas State Univ Manhattan KS USA 66506 Physiol, Manhattan, KS 66506 USA Univ Iowa, Coll Med, Ctr Cardiovasc, Dept Internal Med, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 pt Internal Med, Iowa City, IA 52242 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: H2441 - H2445
SICI:
0363-6135(200112)281:6<H2441:IBABAT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIZED RATS; NEURAL CONTROL; ACTIVATION; THERMOGENESIS; STRESS; SYSTEM; MECHANISMS; AFFERENTS; INJECTION; RECEPTOR;
Keywords:
sympathetic nerve activity; cytokines; chloralose; Sprague-Dawley rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kenney, MJ Kansas State Univ, Dept Anat & Physiol, Coles Hall Rm 228,1600 Denison Ave, Manhattan, KS 66506 USA Kansas State Univ Coles Hall Rm 228,1600 Denison Ave Manhattan KS USA 66506
Citazione:
M.J. Kenney et al., "Interleukin-1 beta alters brown adipose tissue but not renal sympathetic nerve responses to hypothermia", AM J P-HEAR, 281(6), 2001, pp. H2441-H2445

Abstract

Proinflammatory cytokines and acute physical stress influence sympathetic nerve discharge (SND). Because interleukin-1 beta (IL-1 beta) produces physiological responses that require central neural integration and because thesympathetic nervous system mediates physiological responses to environmental stress, we hypothesized that IL-1 beta modulates SND responses to acute physical stress. Therefore, this study examined the effects of IL-1 beta (290 ng/kg iv) and mild hypothermia on renal and interscapular brown adipose tissue (IBAT) SND regulation in chloralose-anesthetized rats. IBAT SND did not change after IL-1 beta administration but was significantly increased during acute mild hypothermia, which was induced 60 min after IL-1 beta treatment. Renal SND was unchanged after IL-1 beta administration and during hypothermia. Acute hypothermia, without prior IL-1 beta administration, did not alter IBAT and renal SND. Increases in IBAT SND during sustained (120 min) hypothermia were significantly higher in IL-1 beta -treated rats compared with saline-treated rats, whereas renal SND responses to sustained hypothermia did not differ among groups. Exposure to acute cold stress after sustained hypothermia produced greater increases in IBAT SND in IL-1 beta -treated rats compared with saline-treated controls. These data suggest that IL-1 beta alters IBAT SND responses to acute and sustained hypothermia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:56:37