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Titolo:
Endothelial NO and prostanoid involvement in newborn and juvenile pig pialarteriolar vasomotor responses
Autore:
Willis, AP; Leffler, CW;
Indirizzi:
Univ Tennessee, Hlth Sci Ctr, Dept Physiol, Lab Res Neonatal Physiol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 onatal Physiol, Memphis, TN 38163 USA Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 r, Dept Pediat, Memphis, TN 38163 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: H2366 - H2377
SICI:
0363-6135(200112)281:6<H2366:ENAPII>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CEREBRAL ARTERIOLES; DEVELOPMENTAL-CHANGES; ACTIVATED OXYGEN; PERMISSIVE ROLE; BRADYKININ; PROSTAGLANDIN; DILATION; PROSTACYCLIN; HYPERCAPNIA;
Keywords:
cranial window; cerebral circulation; permissive; age; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Leffler, CW Univ Tennessee, Hlth Sci Ctr, Dept Physiol, Lab Res Neonatal Physiol, 894 Union Ave, Memphis, TN 38163 USA Univ Tennessee 894 Union Ave Memphis TN USA 38163 TN 38163 USA
Citazione:
A.P. Willis e C.W. Leffler, "Endothelial NO and prostanoid involvement in newborn and juvenile pig pialarteriolar vasomotor responses", AM J P-HEAR, 281(6), 2001, pp. H2366-H2377

Abstract

Specific cerebrovascular dilatory responses in newborn piglets are entirely prostanoid dependent, but require both nitric oxide (NO) and prostanoids in juveniles. We examined endothelial dependency and mechanisms of NO- and prostanoid-mediated cerebrovascular responses in anesthetized newborn and juvenile pigs implanted with closed cranial windows. Light/dye endothelial injury inhibited newborn and juvenile hypercapnic and bradykinin (BK) responses and inhibited dilation to acetylcholine in juveniles. Iloprost and NO act permissively in restoring light/dye inhibited newborn and juvenile responses, respectively. Differences in sensitivity to iloprost and sodium nitroprusside were not observed. Juvenile (not newborn) hypercapnic and BK cerebrovascular responses were sensitive to soluble guanylyl cyclase inhibition. Pial arteriolar diameter and cortical production of prostacyclin, cAMP, and cGMP in response to BK were measured under control conditions, after treatment with indomethacin and/or N-omega-nitro-L-arginine methyl ester (L-NAME). Indomethacin inhibited BK responses in newborns. Juvenile responses were inhibited by L-NAME, and mildly by indomethacin. Cortical 6-keto-PGF(1 alpha), cAMP, and cGMP increased in response to BK in both age groups. Newborn cerebrovascular responses are largely NO independent, but NO becomes moreimportant with maturation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:14:03