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Titolo:
Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines
Autore:
Nanji, AA; Jokelainen, K; Fotouhinia, M; Rahemtulla, A; Thomas, P; Tipoe, GL; Su, GL; Dannenberg, AJ;
Indirizzi:
Queen Mary Hosp, Clin Biochem Unit, LG 136, Hong Kong, Hong Kong, Peoples R China Queen Mary Hosp Hong Kong Hong Kong Peoples R China ong, Peoples R China Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Ctr Study Liver Dis, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China Univ HongKong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Boston Univ, Sch Med, Dept Surg, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Sch Med, Dept Surg, Boston, MA 02118 USA Univ Helsinki, Cent Hosp, Alcohol Dis Res Unit, Helsinki, Finland Univ Helsinki Helsinki Finland Alcohol Dis Res Unit, Helsinki, Finland McGill Univ, Dept Nutr, Montreal, PQ H9X 3V9, Canada McGill Univ MontrealPQ Canada H9X 3V9 Nutr, Montreal, PQ H9X 3V9, Canada Univ Michigan, Med Ctr, Dept Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 r, Dept Med, Ann Arbor, MI 48109 USA Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Coll, Dept Med, New York, NY 10021 USA Strang Canc Prevent Ctr, Anne Fisher Nutr Ctr, New York, NY 10021 USA Strang Canc Prevent Ctr New York NY USA 10021 Ctr, New York, NY 10021 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: G1348 - G1356
SICI:
0193-1857(200112)281:6<G1348:ISOALI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; SATURATED FATTY-ACIDS; LIPID-PEROXIDATION; GENDER DIFFERENCES; PLASMA ENDOTOXIN; GENE-EXPRESSION; HEPATIC-INJURY; DISEASE; ETHANOL; CYCLOOXYGENASE-2;
Keywords:
cytokines; cyclooxygenase-2; tumor necrosis factor-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Nanji, AA Queen Mary Hosp, Clin Biochem Unit, LG 136, Block K,102 PokfulamRd, Hong Kong, Hong Kong, Peoples R China Queen Mary Hosp Block K,102 Pokfulam Rd Hong Kong Hong Kong Peoples R China
Citazione:
A.A. Nanji et al., "Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines", AM J P-GAST, 281(6), 2001, pp. G1348-G1356

Abstract

Alcoholic liver injury is more severe and rapidly developing in women thanmen. To evaluate the reason(s) for these gender-related differences, we determined whether pathogenic mechanisms important in alcoholic liver injury in male rats were further upregulated in female rats. Male and age-matched female rats (7/group) were fed ethanol and a diet containing fish oil for 4wk by intragastric infusion. Dextrose isocalorically replaced ethanol in control rats. We analyzed liver histopathology, lipid peroxidation, cytochrome P-450 (CYP)2E1 activity, nonheme iron, endotoxin, nuclear factor-kappaB (NF-kappaB) activation, and mRNA levels of cyclooxygenase-1 (COX-1) and COX-2, tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1(MCP-1), and macrophage inflammatory protein-2 (MIP-2). Alcohol-induced liver injury was more severe in female vs. male rats. Female rats had higher endotoxin, lipid peroxidation, and nonheme iron levels and increased NF-kappaB activation and upregulation of the chemokines MCP-1 and MIP-2. CYP2E1 activity and TNF-alpha and COX-2 levels were similar in male and female rats. Remarkably, female rats fed fish oil and dextrose also showed necrosis and inflammation. Our findings in ethanol-fed rats suggest that increased endotoxemia and lipid peroxidation in females stimulate NF-kappaB activation and chemokine production, enhancing liver injury. TNF-alpha and COX-2 upregulation are probably important in causing liver injury but do not explain gender-related differences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:54:39