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Titolo:
Nonalcoholic steatosis and steatohepatitis - III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis
Autore:
Reddy, JK;
Indirizzi:
Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Pathol, Chicago, IL 60611 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 6, volume: 281, anno: 2001,
pagine: G1333 - G1339
SICI:
0193-1857(200112)281:6<G1333:NSAS-I>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLIFERATOR-ACTIVATED RECEPTOR; ACYL-COA OXIDASE; LIGAND METABOLISM; MICE LACKING; FATTY-ACIDS; COENZYME-A; MOUSE; LIVER; GENE; DEGRADATION;
Keywords:
peroxisomes; fatty acid beta- and omega-oxidation; peroxisomal proliferator-activated receptor alpha; peroxisomal biogenesis disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Reddy, JK Northwestern Univ, Sch Med, Dept Pathol, 303 E Chicago Ave, Chicago, IL 60611 USA Northwestern Univ 303 E Chicago Ave Chicago IL USA 60611 611 USA
Citazione:
J.K. Reddy, "Nonalcoholic steatosis and steatohepatitis - III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis", AM J P-GAST, 281(6), 2001, pp. G1333-G1339

Abstract

Peroxisomes are involved in the beta -oxidation chain shortening of long-chain and very-long-chain fatty acyl-CoAs, long-chain dicarboxylyl-CoAs, theCoA esters of eicosanoids, 2-methyl-branched fatty acyl-CoAs, and the CoA esters of the bile acid intermediates, and in the process, they generate H2O2. There are two complete sets of beta -oxidation enzymes present in peroxisomes, with each set consisting of three distinct enzymes. The classic PPAR alpha -regulated and inducible set participates in the beta -oxidation ofstraight-chain fatty acids, whereas the second noninducible set acts on branched-chain fatty acids. Long-chain and very-long-chain fatty acids are also metabolized by the cytochrome P-450 CYP4A omega -oxidation system to dicarboxylic acids that serve as substrates for peroxisomal beta -oxidation. Evidence derived from mouse models of PPAR alpha and peroxisomal beta -oxidation deficiency highlights the critical importance of the defects in PPAR alpha- inducible beta -oxidation in energy metabolism and in the developmentof steatohepatitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 12:59:42