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Titolo:
Origins and divergence of the Roma (Gypsies)
Autore:
Gresham, D; Morar, B; Underhill, PA; Passarino, G; Lin, AA; Wise, C; Angelicheva, D; Calafell, F; Oefner, PJ; Shen, PD; Tournev, I; de Pablo, R; Kucinskas, V; Perez-Lezaun, A; Marushiakova, E; Popov, V; Kalaydjieva, L;
Indirizzi:
Edith Cowan Univ, Ctr Human Genet, Perth, WA 6027, Australia Edith Cowan Univ Perth WA Australia 6027 Genet, Perth, WA 6027, Australia Western Australian Inst Med Res, Perth, WA, Australia Western Australian Inst Med Res Perth WA Australia Perth, WA, Australia Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 d, Dept Genet, Stanford, CA 94305 USA Univ Calabria, Dipartimento Biol Cellulare, Arcavacata Di Rende, Italy Univ Calabria Arcavacata Di Rende Italy are, Arcavacata Di Rende, Italy Univ Pompeu Fabra, Fac Ciencies & Vida, Unitat Biol Evolut, Barcelona, Spain Univ Pompeu Fabra Barcelona Spain Unitat Biol Evolut, Barcelona, Spain Stanford Genome Technol Ctr, Palo Alto, CA USA Stanford Genome Technol Ctr Palo Alto CA USA hnol Ctr, Palo Alto, CA USA Med Univ Sofia, Dept Neurol, Sofia, Bulgaria Med Univ Sofia Sofia Bulgaria Univ Sofia, Dept Neurol, Sofia, Bulgaria Fdn Hlth Problems Ethn Minor, Sofia, Bulgaria Fdn Hlth Problems Ethn Minor Sofia Bulgaria Ethn Minor, Sofia, Bulgaria Bulgarian Acad Sci, Inst Ethnol, Sofia, Bulgaria Bulgarian Acad Sci Sofia Bulgaria cad Sci, Inst Ethnol, Sofia, Bulgaria Clin Puerta Hierro, Unidad Immunol, Madrid, Spain Clin Puerta Hierro Madrid Spain a Hierro, Unidad Immunol, Madrid, Spain Univ Vilnius, Fac Med, Ctr Human Genet, Vilnius, Lithuania Univ Vilnius Vilnius Lithuania Med, Ctr Human Genet, Vilnius, Lithuania
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 6, volume: 69, anno: 2001,
pagine: 1314 - 1331
SICI:
0002-9297(200112)69:6<1314:OADOTR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPATHY CCFDN SYNDROME; HOMO-SAPIENS SAPIENS; Y-CHROMOSOME; MITOCHONDRIAL-DNA; SEQUENCE VARIATION; HUMAN-POPULATIONS; FOUNDER MUTATION; CONTROL-REGION; MTDNA; EUROPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Kalaydjieva, L Edith Cowan Univ, Ctr Human Genet, Joondalup Campus, Perth,WA 6027, Australia Edith Cowan Univ Joondalup Campus Perth WA Australia 6027 a
Citazione:
D. Gresham et al., "Origins and divergence of the Roma (Gypsies)", AM J HU GEN, 69(6), 2001, pp. 1314-1331

Abstract

The identification of a growing number of novel Mendelian disorders and private mutations in the Roma (Gypsies) points to their unique genetic heritage. Linguistic evidence suggests that they are of diverse Indian origins. Their social structure within Europe resembles that of the jatis of India, where the endogamous group, often defined by profession, is the primary unit. Genetic studies have reported dramatic differences in the frequencies of mutations and neutral polymorphisms in different Romani populations. However, these studies have not resolved ambiguities regarding the origins and relatedness of Romani populations. In this study, we examine the genetic structure of 14 well-defined Romani populations. Y-chromosome and mtDNA markersof different mutability were analyzed in a total of 275 individuals. AsianY-chromosome haplogroup VI-68, defined by a mutation at the M82 locus, waspresent in all 14 populations and accounted for 44.8% of Romani Y chromosomes. Asian mtDNA-haplogroup M was also identified in all Romani populationsand accounted for 26.5% of female lineages in the sample. Limited diversity within these two haplogroups, measured by the variation at eight short-tandem- repeat loci for the Y chromosome, and sequencing of the HVS1 for the mtDNA are consistent with a small group of founders splitting from a singleethnic population in the Indian subcontinent. Principal-components analysis and analysis of molecular variance indicate that genetic structure in extant endogamous Romani populations has been shaped by genetic drift and differential admixture and correlates with the migrational history of the Roma in Europe. By contrast, social organization and professional group divisions appear to be the product of a more recent restitution of the caste systemof India.

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Documento generato il 23/11/20 alle ore 21:31:55