Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: Identification of new loci with evidence of interactions
Autore:
Holm, P; Julier, C; Kockum, I; Senee, V; Blanc, H; Papp, J; Akesson, K; Bartsocas, C; de Leiva, A; Dahlquist, G; Ronningen, KS; Lathrop, M; Luthman, H; Pociot, F; Nerup, J;
Indirizzi:
Steno Diabet Ctr, DK-2820 Gentofte, Denmark Steno Diabet Ctr Gentofte Denmark DK-2820 Ctr, DK-2820 Gentofte, Denmark Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England Univ Oxford Oxford England lcome Trust Ctr Human Genet, Oxford, England Karolinska Inst, Dept Mol Med, Stockholm, Sweden Karolinska Inst Stockholm Sweden Inst, Dept Mol Med, Stockholm, Sweden Inst Pasteur, Paris, France Inst Pasteur Paris FranceInst Pasteur, Paris, France Univ Calif Los Angeles, Sch Med, Dept Human Genet, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA man Genet, Los Angeles, CA USA Univ Athens, Fac Nursing, Childrens Hosp, GR-10679 Athens, Greece Univ Athens Athens Greece GR-10679 ildrens Hosp, GR-10679 Athens, Greece Univ Autonoma Barcelona, Hosp La Santa Creu & Sat Pau, E-08193 Barcelona, Spain Univ Autonoma Barcelona Barcelona Spain E-08193 E-08193 Barcelona, Spain Umea Univ, Dept Paediat, Umea, Sweden Umea Univ Umea SwedenUmea Univ, Dept Paediat, Umea, Sweden Natl Publ Hlth Inst, Lab Mol Epidemiol, Oslo, Norway Natl Publ Hlth Inst Oslo Norway h Inst, Lab Mol Epidemiol, Oslo, Norway
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 6, volume: 69, anno: 2001,
pagine: 1301 - 1313
SICI:
0002-9297(200112)69:6<1301:AGSFT1>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; INSULIN GENE REGION; CHILDREN 0-14 YEARS; ASSOCIATION ANALYSIS; MULTIPLE-SCLEROSIS; LINKAGE DISEQUILIBRIUM; PAIR FAMILIES; IDDM PATIENTS; TIME TRENDS; AGE GROUP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Nerup, J Steno Diabet Ctr, Niels Steensens Vej 2, DK-2820 Gentofte, Denmark Steno Diabet Ctr Niels Steensens Vej 2 Gentofte Denmark DK-2820
Citazione:
P. Holm et al., "A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: Identification of new loci with evidence of interactions", AM J HU GEN, 69(6), 2001, pp. 1301-1313

Abstract

Type 1 diabetes mellitus (TIDM) has a multifactorial etiology, with major genetic-susceptibility determinants located in the HLA and insulin-gene (INS) regions. Linkage data implicating other disease-susceptibility loci are conflicting. This is likely due to (1) the limited power for detection of contributions of additional susceptibility loci, given the limited number ofinformative families available for study, (2) factors such as genetic heterogeneity between populations, and (3) potential gene-gene and gene-environment interactions. To circumvent some of these problems, we have conducted a genomewide linkage analysis for T1DM-susceptibility loci in 408 multiplexfamilies from Scandinavia, a population expected to be homogeneous for genetic and environmental factors. In addition to verifying the HLA and INS susceptibility loci, the study provides confirmation of IDDM15 on chromosome 6q21. Suggestive evidence of additional susceptibility loci was found on chromosomes 2p, 5q, and 16p. For some loci, the support for linkage increasedsubstantially when families were stratified on the basis of HLA or INS genotypes, with statistically significant heterogeneity between the stratifiedsubgroups. Our data support both the existence of non-HLA genes of significance for T1DM and interaction between HLA and non-HLA loci in the determination of the T1DM phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:28:24