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Titolo:
Mediator antagonists in the treatment of allergic disease
Autore:
DuBuske, LM;
Titolo Testata:
ALLERGY AND ASTHMA PROCEEDINGS
fascicolo: 5, volume: 22, anno: 2001,
pagine: 261 - 275
SICI:
1088-5412(200109/10)22:5<261:MAITTO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLUBLE IL-4 RECEPTOR; INDUCED RHINITIS; T-CELLS; NASAL ALLERGY; GUINEA-PIGS; IN-VITRO; LORATADINE; HISTAMINE; RELEASE; ASTHMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: DuBuske, LM 358 Elm St, Gardner, MA 01440 USA 358 Elm St Gardner MA USA 01440 Elm St, Gardner, MA 01440 USA
Citazione:
L.M. DuBuske, "Mediator antagonists in the treatment of allergic disease", ALL ASTH P, 22(5), 2001, pp. 261-275

Abstract

New approaches to allergic inflammation include specific cytokine antagonists and monoclonal antibodies against IgE, against chemokines, and against adhesion molecules. Currently available therapies, such as leukotriene antagonists, may soon be approved for allergic rhinitis. New generation antihistamines such as desloratadine have wide-ranging anti-allergic, anti-inflammatory profiles, including suppression of cytokine, chemokine, and adhesion molecule expression. Recent desloratadine studies have demonstrated that this highly potent H-1 receptor antagonist consistently provides relief of nasal congestion and may, provide benefits similar to montelukast in mild asthma patients. New generation intra-nasal corticosteroids such as fluticasone and mometasone provide high corticosteroid potency while being minimally bioavailable when administered as intranasal preparations. Future advances in allergy therapy also include improved T-cell selective formats of immunotherapy. The range of therapies for allergic rhinitis is likely to substantially increase in the coming years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:24:57