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Titolo:
Increasing impact of chronic viral hepatitis on hospital admissions and mortality among HIV-infected patients
Autore:
Martin-Carbonero, L; Soriano, V; Valencia, E; Garcia-Samaniego, J; Lopez, M; Gonzalez-Lahoz, J;
Indirizzi:
Hosp Carlos III, Inst Salud Carlos III, Infect Dis Serv, Madrid 28035, Spain Hosp Carlos III Madrid Spain 28035 Infect Dis Serv, Madrid 28035, Spain Hosp Carlos III, Inst Salud Carlos III, Serv Hepatol, Madrid 28035, Spain Hosp Carlos III Madrid Spain 28035 II, Serv Hepatol, Madrid 28035, Spain
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 16, volume: 17, anno: 2001,
pagine: 1467 - 1471
SICI:
0889-2229(200111)17:16<1467:IIOCVH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; ANTIRETROVIRAL THERAPY; LIVER-DISEASE; HEPATOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Soriano, V Calle Nueva Zelanda 54,4 B, Madrid 28035, Spain Calle Nueva Zelanda 54,4 B Madrid Spain 28035 id 28035, Spain
Citazione:
L. Martin-Carbonero et al., "Increasing impact of chronic viral hepatitis on hospital admissions and mortality among HIV-infected patients", AIDS RES H, 17(16), 2001, pp. 1467-1471

Abstract

To assess the impact of chronic viral liver disease (CVLD) on hospital admissions and death in HIV-infected patients since the introduction of highlyactive antiretroviral therapy, all hospital charts, from January 1996 to December 2000, in a large HIV/AIDS reference center in Madrid were reviewed. Discharge diagnosis, complications during the inpatient period, and numberand causes of death were recorded. A total of 1334 hospital admissions involving 875 HIV-infected individuals was recorded. Up to 82% of them were either active or former intravenous drug users. Overall, 158 (11.8%) were admitted because of complications of CVLD, or developed complications of CVLD during their admission for another reason. The absolute number and proportion of admissions caused by CVLD increased over time, from 9.4% (31 of 330) in 1996 to 16% (46 of 287) in 2000 (p<0.05). Likewise, the total number andproportion of deaths due to CVLD increased from 9.3% (5 of 54) in 1996 to 45% (9 of 20) in 2000 (p<0.05). Chronic hepatitis C was the only etiology in nearly three-quarters of patients who were admitted or died of CVLD. In conclusion, the proportion of hospital admissions caused by liver failure inHIV-infected patients has increased in the last 5 years, accounting for 16% of cases in 2000. End-stage liver disease currently represents 45% of causes of in-hospital death among HIV-infected individuals. Therefore, strategies to prevent infection by hepatitis viruses (hepatitis B vaccine) and specific treatment (interferon plus ribavirin for hepatitis C virus) should beencouraged among HIV-infected persons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:08:46