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Titolo:
Marginal-zone B-cell lymphoma of extranodal mucosa-associated lymphoid tissue type: Molecular genetics provides new insights into pathogenesis
Autore:
Vega, F; Medeiros, LJ;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Div Pathol & Lab Med, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 v Pathol & Lab Med, Houston, TX 77030 USA
Titolo Testata:
ADVANCES IN ANATOMIC PATHOLOGY
fascicolo: 6, volume: 8, anno: 2001,
pagine: 313 - 319
SICI:
1072-4109(200111)8:6<313:MBLOEM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
T(11-18)(Q21-Q21); TRANSLOCATION;
Keywords:
extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT); molecular genetics; t(11;8)-api2-malt1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Medeiros, LJ Univ Texas, MD Anderson Canc Ctr, Dept Hematopathol, 1515 Holcombe Blvd,Box 72, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd,Box 72 Houston TX USA 77030 USA
Citazione:
F. Vega e L.J. Medeiros, "Marginal-zone B-cell lymphoma of extranodal mucosa-associated lymphoid tissue type: Molecular genetics provides new insights into pathogenesis", ADV ANAT PA, 8(6), 2001, pp. 313-319

Abstract

Marginal zone B-cell lymphoma of extranodal mucosa-associated lymphoid tissue (MALT) type is recognized as a distinct clinicopathologic entity in therevised European-American lymphoma (REAL) and recently published World Health Organization (WHO) classifications. These neoplasms are thought to arise from the extranodal equivalent of the lymph node marginal zone. Two recurrent chromosomal translocations, to date, have been implicated in the pathogenesis of these neoplasms. The t(11;18)(q21;q21), which is far more common, disrupts the api2 gene on chromosome 11q21 and the malt1 (mlt) gene on chromosome 18q21, resulting in the synthesis of a novel fusion gene and protein, AP12-MALT1. The t(1;14)(p22:q32), which is uncommon, juxtaposes the bcl-10 gene on chromosome 1p22 adjacent to the immunoglobulin heavy chain (IgH) gene on chromosome 14, wherein BCL10 is overexpressed via the influence of the IgH enhancer. BCL-10 may then form a complex with MALT I in the cell. Both translocations result in increased inhibition of apoptosis, conferring a survival advantage. Recent work suggests that AP12-MALT1 and BCL10-MALT1 may activate NF-kB and a common downstream signaling pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:20:29