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Titolo:
Histopathological prognostic factors of adult granulosa cell tumors of theovary
Autore:
Fujimoto, T; Sakuragi, N; Okuyama, K; Fujino, T; Yamashita, K; Yamashiro, S; Shimizu, M; Fujimoto, S;
Indirizzi:
Hokkaido Univ Hosp, Dept Obstet & Gynecol, Sapporo, Hokkaido, Japan Hokkaido Univ Hosp Sapporo Hokkaido Japan ecol, Sapporo, Hokkaido, Japan Hokkaido Univ Hosp, Div Surg Pathol, Sapporo, Hokkaido, Japan Hokkaido Univ Hosp Sapporo Hokkaido Japan thol, Sapporo, Hokkaido, Japan Sapporo Natl Hosp, Div Obstet & Gynecol, Sapporo, Hokkaido, Japan Sapporo Natl Hosp Sapporo Hokkaido Japan necol, Sapporo, Hokkaido, Japan Sapporo Natl Hosp, Div Pathol, Sapporo, Hokkaido, Japan Sapporo Natl HospSapporo Hokkaido Japan athol, Sapporo, Hokkaido, Japan
Titolo Testata:
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
fascicolo: 11, volume: 80, anno: 2001,
pagine: 1069 - 1074
SICI:
0001-6349(200111)80:11<1069:HPFOAG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOHISTOCHEMICAL ANALYSIS; SUPPRESSOR GENE; P53;
Keywords:
adult granulosa cell tumor; lymph-vascular space invasion; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sakuragi, N Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 o 0608638, Japan
Citazione:
T. Fujimoto et al., "Histopathological prognostic factors of adult granulosa cell tumors of theovary", ACT OBST SC, 80(11), 2001, pp. 1069-1074

Abstract

Background. The prognostic factors of adult granulosa cell tumor (AG-CT) have not been well defined. Methods. In 27 AGCT patients, we examined clinical stage, microscopic patterns, mitotic index (MI), and lymph-vascular space invasion (LVSI) to determine whether these factors were related to disease-free survival (DFS) of patients with AG-CT. We also performed immunohistochemical examination for p53. Results. Seventeen cases represented stage I tumors, four stage II, five stage III, and one stage IV Patients with stage I disease had more favorableprognosis than those with stage II to IV disease (p=0.034). There was no relation between the microscopic patterns and the DFS. The MI, which was categorized into less than or equal to3/10high power field (HPF) and greater than or equal to4/10 HPF, was significantly related to patients DFS (p <0.0005). The DFS time for patients with moderate or prominent LVSI was significantly shorter than that for patients with no or minimal LVSI (p <0.0001) Bymultivariate analysis, MI and LVSI were shown to be independent prognosticfactors. Five of seven patients with recurrent tumor had extrapelvic spread; two in the abdominal cavity and three in the liver. Conclusion. The results of this study suggest that prognosis for patients with AGCT depends on the MI and LVSI. During the follow-up period of patients, they need to be examined for distant metastasis including liver.

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Documento generato il 30/11/20 alle ore 11:37:05