Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Plasma concentrations of ropivacaine following a single-shot caudal block of 1, 2 or 3 mg/kg in children
Autore:
Bosenberg, AT; Thomas, J; Lopez, T; Huledal, G; Jeppsson, L; Larsson, LE;
Indirizzi:
Univ Natal, Dept Anaesthesia, Fac Med, ZA-4013 Durban, South Africa Univ Natal Durban South Africa ZA-4013 Med, ZA-4013 Durban, South Africa Red Cross War Mem Childrens Hosp, Dept Anaesthesia, Cape Town, South Africa Red Cross War Mem Childrens Hosp Cape Town South Africa n, South Africa AstraZeneca Sodertalje, Clin R&D, Sodertalje, Sweden AstraZeneca Sodertalje Sodertalje Sweden , Clin R&D, Sodertalje, Sweden
Titolo Testata:
ACTA ANAESTHESIOLOGICA SCANDINAVICA
fascicolo: 10, volume: 45, anno: 2001,
pagine: 1276 - 1280
SICI:
0001-5172(200111)45:10<1276:PCORFA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-1-ACID GLYCOPROTEIN; PEDIATRIC-PATIENTS; BUPIVACAINE; PHARMACOKINETICS; SURGERY; CHROMATOGRAPHY; ANESTHESIA; BINDING;
Keywords:
ropivacaine; pediatric; regional anesthesia; caudal; pharmacokinetics; plasma concentration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Bosenberg, AT Univ Natal, Dept Anaesthesia, Fac Med, Private Bag 7, ZA-4013 Durban, South Africa Univ Natal Private Bag 7 Durban South Africa ZA-4013 Africa
Citazione:
A.T. Bosenberg et al., "Plasma concentrations of ropivacaine following a single-shot caudal block of 1, 2 or 3 mg/kg in children", ACT ANAE SC, 45(10), 2001, pp. 1276-1280

Abstract

Background: For documenting the properties of ropivacaine used for regional anaesthesia in children, the relationship between dose and resulting systemic exposure is essential. The aim of this pharmacokinetic part of a randomised, multicentre, double-blind study was to determine the free and total plasma levels of ropivacaine in children aged between 4 and 12 years following a single-shot caudal dose of 1, 2 or 3 mg/kg of ropivacaine for postoperative pain management. Method: Following induction of a standardised general anaesthetic (halothane; nitrous oxide: oxygen 60:40), a caudal block using 1 ml/kg ropivacaine in concentrations of 1, 2 or 3 mg/ml was performed in 43 ASA I children (body weight 12-25 kg) scheduled for elective inguinal surgery. Blood samples were collected prior to and 15, 30, 45, 60 and 240 min after placement of the caudal block for determination of total and free ropivacaine plasma concentrations. Results: The peak plasma concentration of total ropivacaine, reached within 15-241 min after the block, increased in pro- portion to dose, with mean values at 0.27, 0.64 and 0.90 mg/l following 1, 2 and 3 mg/kg respectively. The peak plasma level of free ropivacaine also increased in a dose-proportional manner, with mean levels at 0.014, 0.030 and 0.042 mg/l. The highest individual peak plasma level of free ropivacaine was 0.070 mg/l, well belowthe threshold levels of CNS toxicity described in adults. No clinical signs of systemic toxicity were observed. Conclusion: Following single-shot caudal doses of 1-3 mg/kg in children upto 25 kg and aged between 4 and 12 years, plasma levels of free ropivacaine increase in proportion to dose and all were shown to be within safe limits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:44:04