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Titolo:
Characterization of a cluster of late genes of guinea pig cytomegalovirus
Autore:
Liu, YG; Biegalke, BJ;
Indirizzi:
Ohio Univ, Coll Osteopath Med, Dept Biomed Sci, Grad Program Biol Sci, Athens, OH 45701 USA Ohio Univ Athens OH USA 45701 Grad Program Biol Sci, Athens, OH 45701 USA Ohio Univ, Mol & Cellular Biol Program, Athens, OH 45701 USA Ohio Univ Athens OH USA 45701 Cellular Biol Program, Athens, OH 45701 USA
Titolo Testata:
VIRUS GENES
fascicolo: 3, volume: 23, anno: 2001,
pagine: 247 - 256
SICI:
0920-8569(2001)23:3<247:COACOL>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
COUPLED RECEPTOR GENE; COMPLETE DNA-SEQUENCE; MURINE CYTOMEGALOVIRUS; CODING CONTENT; MOLECULAR CHARACTERIZATION; TRANSIENT COMPLEMENTATION; TRANSCRIPTIONAL ANALYSIS; NUCLEOTIDE-SEQUENCE; ACIDIC DOMAIN; PROTEIN;
Keywords:
guinea pig cytomegalovirus; UL33; UL34; UL35; G protein-coupled receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Biegalke, BJ Ohio Univ, Coll Osteopath Med, Dept Biomed Sci, Grad Program Biol Sci, 228Irvine Hall, Athens, OH 45701 USA Ohio Univ 228 Irvine Hall Athens OH USA 45701 s, OH 45701 USA
Citazione:
Y.G. Liu e B.J. Biegalke, "Characterization of a cluster of late genes of guinea pig cytomegalovirus", VIRUS GENES, 23(3), 2001, pp. 247-256

Abstract

Human cytomegalovirus (HCMV) is the most common congenital infection, and is associated with a high rate of morbidity and mortality in the newborn infant. Guinea pig cytomegalovirus (GPCMV) is transmitted through the placenta with resulting fetal infection, and provides an excellent model for the study of fetal cytomegalovirus infection. We have characterized a cluster oflate GPCMV genes, identifying GPCMV homologs of the HCMV G protein-coupledreceptor gene, UL33; the transcriptional repressor gene, UL34 and two genes encoding tegument proteins, UL32 and UL35. We also identified the GPCMV homolog of UL37, an antiapoptotic gene. Surprisingly, no GPCMV homolog to HCMV UL36 was identified in the same genomic region. Furthermore, two of the predicted GPCMV proteins share greater identity with HHV-6 and/or HHV-7 homologs than with other cytomegalovirus homologs. The identification of GPCMVhomologs of conserved viral genes, particularly genes involved in pathogenicity such as the G protein-coupled receptors, will facilitate future analysis of the role of these genes in infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 14:42:14