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Titolo:
INHIBITORS OF NUCLEAR FACTOR KAPPA-B CAUSE APOPTOSIS IN CULTURED MACROPHAGES
Autore:
MANNICK EE; MISHRA J; MARQUE J; CLAVELL M; MILLER MJS; OLIVER PD;
Indirizzi:
LOUISIANA STATE UNIV,DEPT PEDIAT NEW ORLEANS LA 70112
Titolo Testata:
Mediators of inflammation
fascicolo: 3, volume: 6, anno: 1997,
pagine: 225 - 232
SICI:
0962-9351(1997)6:3<225:IONFKC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMOCYTE APOPTOSIS; CELL-LINE; ACTIVATION; ALPHA; PATHWAY; PHOSPHORYLATION; PROTEOLYSIS; PROTEASE; RECEPTOR; BCL-2;
Keywords:
APOPTOSIS; MACROPHAGE; NUCLEAR FACTOR KAPPA-B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
E.E. Mannick et al., "INHIBITORS OF NUCLEAR FACTOR KAPPA-B CAUSE APOPTOSIS IN CULTURED MACROPHAGES", Mediators of inflammation, 6(3), 1997, pp. 225-232

Abstract

The precise role of the transcription factor nuclear factor kappa B (NF-kappa B) in the regulation of cell survival and cell death is stillunresolved and may depend on cell type and position in the cell. cycle. The aim of this study was to determine if three pharmacologic inhibitors of NF-kappa B, pyrrolidine dithiocarbamate, N-tosyl-L-lysl chloromethyl ketone and calpain I inhibitor, induce apoptosis in a murine macrophage cell line (RAW 264.7) at doses similar to those required forNF-kappa B inhibition. We found that each of the three inhibitors resulted in a dose- and time-dependent increase in morphologic indices ofapoptosis in unstimulated, LPS-stimulated and TNF-stimulated cells. Lethal doses were consistent with those required for NF-kappa B inhibition. We conclude that nuclear NF-kappa B activation may represent an important survival mechanism in macrophages.

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Documento generato il 24/09/20 alle ore 20:25:32