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Titolo:
Surgical strategies and minimal residual disease detection
Autore:
Weitz, J; Herfarth, C;
Indirizzi:
Univ Heidelberg, Dept Surg, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany
Titolo Testata:
SEMINARS IN SURGICAL ONCOLOGY
fascicolo: 4, volume: 20, anno: 2001,
pagine: 329 - 333
SICI:
8756-0437(200106)20:4<329:SSAMRD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; LYMPH-NODE METASTASES; TUMOR-CELL DISSEMINATION; COLORECTAL-CANCER; HEMATOGENOUS DISSEMINATION; HEPATOCELLULAR-CARCINOMA; PROGNOSTIC-SIGNIFICANCE; REVERSE TRANSCRIPTION; MALIGNANT-MELANOMA; HEPATIC RESECTION;
Keywords:
disseminated tumor cells; surgery; intraoperative tumor cell shedding; individualized therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Weitz, J Univ Heidelberg, Dept Surg, Kirschnerstr 1, D-69120 Heidelberg, Germany Univ Heidelberg Kirschnerstr 1 Heidelberg Germany D-69120 ermany
Citazione:
J. Weitz e C. Herfarth, "Surgical strategies and minimal residual disease detection", SEM SURG ON, 20(4), 2001, pp. 329-333

Abstract

The ultimate goal in the treatment of cancer patients is the elimination of all tumor cells. A cure by surgery alone is possible only if the tumor isstill confined locally. Detection of disseminated tumor cells may help to individually tailor the surgical procedure to each patient: extended or limited resections may be indicated depending on the individual state of tumorcell dissemination. In cases of systemic tumor cell dissemination, surgeryalone cannot cure the patient. Thus, by detecting disseminated tumor cells, patients with a higher risk for relapse, who might benefit from multimodal therapeutic regimes, could be defined. A second aspect is the possibilityof tumor cell shedding induced by manipulation during surgical procedures,which could be demonstrated for several tumor entities. Intraoperative tumor cell dissemination could be prevented by alternative operative strategies. In addition, perioperative antibody or cytotoxic therapy may prevent tumor cell implantation. Well-designed clinical studies are now of major importance to evaluate the clinical impact of individualized patient management and altered surgical procedures. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:21:06