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Titolo:
Defective antigen processing in GILT-free mice
Autore:
Maric, M; Arunachalam, B; Phan, UT; Dong, C; Garrett, WS; Cannon, KS; Alfonso, C; Karlsson, L; Flavell, RA; Cresswell, P;
Indirizzi:
Yale Univ, Howard Hughes Med Inst, Immunol Sect, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 t, Immunol Sect, New Haven, CT 06520 USA RW Johnson Pharmaceut Res Inst, San Diego, CA 92121 USA RW Johnson Pharmaceut Res Inst San Diego CA USA 92121 Diego, CA 92121 USA
Titolo Testata:
SCIENCE
fascicolo: 5545, volume: 294, anno: 2001,
pagine: 1361 - 1365
SICI:
0036-8075(20011109)294:5545<1361:DAPIGM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
THIOL REDUCTASE GILT; T-CELL ACTIVATION; DISULFIDE BONDS; DENDRITIC CELLS; HEN LYSOZYME; LYSOSOMES; CONFORMATION; GENERATION; CYSTEINE; MHC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Cresswell, P Yale Univ, Howard Hughes Med Inst, Immunol Sect, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ct, New Haven, CT 06520 USA
Citazione:
M. Maric et al., "Defective antigen processing in GILT-free mice", SCIENCE, 294(5545), 2001, pp. 1361-1365

Abstract

Processing of proteins for major histocompatibility complex (MHC) class II-restricted presentation to CD4-positive T lymphocytes occurs after they are internalized by antigen-presenting cells (APCs). Antigenic proteins frequently contain disulfide bonds, and their reduction in the endocytic pathwayfacilitates processing. In humans, a gamma interferon-inducible lysosomal thiol reductase (GILT) is constitutively present in late endocytic compartments of APCs. Here, we identified the mouse homolog of GILT and generated aGILT knockout mouse. GILT facilitated the processing and presentation to antigen-specific T cells of protein antigens containing disulfide bonds. Theresponse to hen egg lysozyme, a model antigen with a compact Structure containing four disulfide bonds, was examined in detail.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:24:11