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Titolo:
Cerebral complications of hypertension in the elderly.
Autore:
Rigaud, AS; Hanon, O; Bouchacourt, P; Forette, F;
Indirizzi:
CHU Cochin Port Royal, Hop Broca, Serv Gerontol, F-75013 Paris, France CHUCochin Port Royal Paris France F-75013 rontol, F-75013 Paris, France
Titolo Testata:
REVUE DE MEDECINE INTERNE
fascicolo: 10, volume: 22, anno: 2001,
pagine: 959 - 968
SICI:
0248-8663(200110)22:10<959:CCOHIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
FRE
Soggetto:
ISOLATED SYSTOLIC HYPERTENSION; MENTAL-STATE-EXAMINATION; CORONARY HEART-DISEASE; HIGH-BLOOD-PRESSURE; EUROPEAN-WORKING-PARTY; COGNITIVE FUNCTION; ANTIHYPERTENSIVE TREATMENT; VASCULAR DEMENTIA; OLDER PATIENTS; RISK-FACTORS;
Keywords:
hypertension; elderly; brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Rigaud, AS CHU Cochin Port Royal, Hop Broca, Serv Gerontol, 54-56 Rue Pascal, F-75013Paris, France CHU Cochin Port Royal 54-56 Rue Pascal Paris France F-75013 ce
Citazione:
A.S. Rigaud et al., "Cerebral complications of hypertension in the elderly.", REV MED IN, 22(10), 2001, pp. 959-968

Abstract

Purpose. - This review focuses on cerebral complications of hypertension, which include stroke, impairment of cognitive function, dementia, and possibly depression and anxiety. These conditions are major causes of morbidity and mortality in the elderly. Current knowledge and key points. - Not only elevated diastolic blood pressure, but also isolated systolic hypertension and elevated pulse pressure play an important role in the development of brain complications. Randomisedplacebo-controlled trials have provided evidence that reduction of hypertension decreases safely and effectively morbidity and mortality rates in theelderly. The new classes of drugs, in particular calcium-channels blockorsand angiotensin-converting enzyme inhibitors, have been shown to be as effective as the originally used diuretics and beta-blockers. Future prospects and projects. - Several trials are currently in progress and should provide more information on the benefit of antihypertensive treatment in very elderly persons (Hypertension in the Very Elderly Trial, HYVET) and secondary prevention of stroke (PROGRESS). The importance of assessing new dosages of the presently used antihypertensive drugs as well as the benefit of new classes of drugs is emphasised. Further trials specifically focusing on the prevention of dementia by antihypertensive drugs are neededto confirm the results of the Syst-Eur Vascular Dementia Project. The benefit of calcium antagonists in the prevention of dementia in elderly hypertensive patients should be assessed in the Dementia Prevention in Hypertension trial (DEPHY). (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:22:15