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Titolo:
Serum levels of vascular endothelial growth factor and cavity formation inactive pulmonary tuberculosis
Autore:
Abe, Y; Nakamura, M; Oshika, Y; Hatanaka, H; Tokunaga, T; Ohkubo, Y; Hashizume, T; Suzuki, K; Fujino, T;
Indirizzi:
Natl Sanatorium Kanagawa Hosp, Dept Resp Dis, Hadano, Kanagawa 2578585, Japan Natl Sanatorium Kanagawa Hosp Hadano Kanagawa Japan 2578585 578585, Japan Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa 25911, Japan Tokai Univ Isehara Kanagawa Japan 25911 l, Isehara, Kanagawa 25911, Japan
Titolo Testata:
RESPIRATION
fascicolo: 5, volume: 68, anno: 2001,
pagine: 496 - 500
SICI:
0025-7931(200109/10)68:5<496:SLOVEG>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MYCOBACTERIUM-TUBERCULOSIS; FACTOR-ALPHA; FACTOR VEGF; EXPRESSION; INFECTION; DISEASE; CANCER; ANGIOGENESIS; CORRELATE;
Keywords:
vascular endothelial growth factor; tuberculosis; lung; cavity; high-resolution computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, Y Natl Sanatorium Kanagawa Hosp, Dept Resp Dis, 666-1 Ochiai, Hadano,Kanagawa 2578585, Japan Natl Sanatorium Kanagawa Hosp 666-1 Ochiai Hadano Kanagawa Japan 2578585
Citazione:
Y. Abe et al., "Serum levels of vascular endothelial growth factor and cavity formation inactive pulmonary tuberculosis", RESPIRATION, 68(5), 2001, pp. 496-500

Abstract

Background. In active pulmonary tuberculosis, certain cytokines have been postulated to be related to cavity formation, although the detailed mechanism of cavity formation is not yet known. Objective: We examined the relationship between cavity formation in pulmonary tuberculosis and vascular endothelial growth factor (VEGF), which functions as an angiogenesis factor. Methods: Forty-eight patients with active pulmonary tuberculosis were divided into two groups according to cavity formation as evaluated by chest high-resolution computed tomography. We evaluated serum VEGF levels by enzyme immunoassay. Results: Group A (with cavities) was comprised of 22 patients and group B (without cavities) was comprised of 26 patients. The serum levels of VEGF were significantly higher in group B (58.733 +/- 21.612 pg/ml) than those in normal individuals (8.739 +/- 3.656 pg/ml) and in group A (13.053 /- 8.670 pg/ml) (Mann-Whitney U test, p = 0.0149 and p = 0.0481, respectively). Serum levels of interleukin-8 and tumor necrosis factor-alpha were not significantly different between the two groups. Conclusion: These findings suggested that increased serum VEGF levels subdue cavity formation in active pulmonary tuberculosis. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:01:30