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Titolo:
MR renography with low-dose gadopentetate dimeglumine: Feasibility
Autore:
Lee, VS; Rusinek, H; Johnson, G; Rofsky, NM; Krinsky, GA; Weinreb, JC;
Indirizzi:
NYU, Dept Radiol MRI, New York, NY 10016 USA NYU New York NY USA 10016NYU, Dept Radiol MRI, New York, NY 10016 USA
Titolo Testata:
RADIOLOGY
fascicolo: 2, volume: 221, anno: 2001,
pagine: 371 - 379
SICI:
0033-8419(200111)221:2<371:MRWLGD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; RENAL-ARTERY STENOSIS; GD-DTPA; RENOVASCULAR HYPERTENSION; BREATH-HOLD; ANGIOGRAPHY; CAPTOPRIL; DIAGNOSIS; KIDNEY; ECHO;
Keywords:
kidney, function; magnetic resonance (MR), vascular studies; renal arteries, stenosis or obstruction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, VS NYU, Dept Radiol MRI, 530 1st Ave,HCC Basement, New York, NY 10016USA NYU 530 1st Ave,HCC Basement New York NY USA 10016 k, NY 10016 USA
Citazione:
V.S. Lee et al., "MR renography with low-dose gadopentetate dimeglumine: Feasibility", RADIOLOGY, 221(2), 2001, pp. 371-379

Abstract

PURPOSE: To develop a low-dose magnetic resonance (MR) renographic method performed with and without an angiotensin converting enzyme (ACE) inhibitorand in conjunction with gadolinium-enhanced MR angiography in patients with suspected renovascular disease. MATERIALS AND METHODS: Thirty-two patients underwent MR renography (turbo fast low-angle shot sequence: repetition time, 5 msec; echo time, 2.3 msec;flip angle, 15 degrees; one coronal image acquired every 2 seconds for 4 minutes) following intravenous injection of 2 mL of gadopentetate dimeglumine, which was repeated following intravenous injection of an ACE inhibitor. Contrast material-enhanced MR angiography was also performed. On the basis of renographic findings, renal cortex and renal medulla enhancement curves and normalized enhancement ratios were analyzed. RESULTS: The cortex and medulla showed an early transient period of enhancement within 20 seconds (vascular phase). During 1-2 minutes, a second, gradual increase in medullary enhancement, reflecting transit of filtered contrast material, was observed that was significantly greater in patients witha serum creatinine level less than 2 mg/dL (177 mu mol/L) than in those with a level of 2 mg/dL or greater (P <.01). After injection of the ACE inhibitor, patients with elevated creatinine levels showed low renal medullary enhancement regardless of the presence of renal artery stenosis (RAS). However, in patients with creatinine less than 2 mg/dL, medullary enhancement ratios after injection of the ACE inhibitor were consistently lower in patients with RAS of 50% or greater than in those without stenosis (P =.02 to .08). CONCLUSION: Low-dose MR renography can be performed in the clinical setting before and after injection of an ACE inhibitor, and its potential use forevaluating decreased renal function as a consequence of RAS is promising.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:22:51