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Titolo:
Renal fibrosis: Prediction from acute pyelonephritis focus volume measuredat (TC)-T-99m dimercaptosuccinic acid SPECT
Autore:
Chiou, YY; Wang, ST; Tang, MJ; Lee, BF; Chiu, NT;
Indirizzi:
Natl Cheng Kung Univ, Med Ctr & Coll Med, Dept Pediat, Tainan 704, Taiwan Natl Cheng Kung Univ Tainan Taiwan 704 , Dept Pediat, Tainan 704, Taiwan Natl Cheng Kung Univ, Med Ctr & Coll Med, Inst Clin Med Sci, Tainan 704, Taiwan Natl Cheng Kung Univ Tainan Taiwan 704 Clin Med Sci, Tainan 704, Taiwan
Titolo Testata:
RADIOLOGY
fascicolo: 2, volume: 221, anno: 2001,
pagine: 366 - 370
SICI:
0033-8419(200111)221:2<366:RFPFAP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY-TRACT INFECTIONS; CORTICAL SCINTIGRAPHY; DMSA SCINTIGRAPHY; CHILDREN; REFLUX; SCAN; DIAGNOSIS; THERAPY; FOLLOW; INJURY;
Keywords:
kidney, infection; kidney, SPECT; nephritis; single photon emission computed tomography (SPECT), in infants and children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Chiu, NT Natl Cheng Kung Univ, Med Ctr & Coll Med, Dept Pediat, 138 Sheng Li Rd, Tainan 704, Taiwan Natl Cheng Kung Univ 138 Sheng Li Rd Tainan Taiwan 704 4, Taiwan
Citazione:
Y.Y. Chiou et al., "Renal fibrosis: Prediction from acute pyelonephritis focus volume measuredat (TC)-T-99m dimercaptosuccinic acid SPECT", RADIOLOGY, 221(2), 2001, pp. 366-370

Abstract

PURPOSE: To evaluate whether acute pyelonephritis lesion volume derived from acute technetium 99m (Tc-99m) dimercaptosuccinic acid (DMSA) renal single photon emission computed tomographic (SPECT) images is predictive of the development of subsequent renal fibrosis. MATERIALS AND METHODS: Children with acute pyelonephritis underwent Tc-99mDMSA renal SPECT during acute infection and 6-10 months later. At quantitative analysis, the volume of photopenic lesions and the ratio of radioactivity in the photopenic lesion to that in normal renal tissue were calculated. Sensitivity, specificity, and positive and negative predictive values were determined. RESULTS: Sixty-nine acute pyelonephritis foci in 44 children were analyzed. Thirty-seven (54%) of these lesions were normal on follow-up renal scans,while 32 (46%) developed scars. Significant differences in the photopenic lesion volume were found between the two groups (P <.001). When photopenic lesion volume indicated a positive diagnosis (<greater than or equal to>4.6-cm(3) lesion volume), sensitivity, specificity, positive predictive, and negative predictive values were 96.7%, 92.3%, 90.6%, and 97.3%, respectively. CONCLUSION: Quantitative analysis of acute DMSA renal SPECT findings is valuable in predicting renal fibrosis. The volume of an acute pyelonephritis lesion is useful in predicting the development of fibrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:57:26