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Titolo:
Structural brain abnormalities in patients with schizophrenia, epilepsy, and epilepsy with chronic interictal psychosis
Autore:
Marsh, L; Sullivan, EV; Morrell, M; Lim, KO; Pfefferbaum, A;
Indirizzi:
Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t & Behav Sci, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Neurol & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 l & Behav Sci, Stanford, CA 94305 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 108, anno: 2001,
pagine: 1 - 15
SICI:
0925-4927(20011105)108:1<1:SBAIPW>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; RESONANCE-IMAGING ABNORMALITIES; HIPPOCAMPAL VOLUME DEFICITS; PSYCHOMOTOR EPILEPSY; AFFECTIVE-DISORDERS; CHRONIC-ALCOHOLICS; MATTER; MRI; GRAY; SPECIFICITY;
Keywords:
temporal lobe; cortex; MRI; seizures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Marsh, L Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Div Psychiat Neuroimaging, 600 N Wolfe St,Meyer 3-166, Baltimore, MD 21287 USA JohnsHopkins Univ 600 N Wolfe St,Meyer 3-166 Baltimore MD USA 21287
Citazione:
L. Marsh et al., "Structural brain abnormalities in patients with schizophrenia, epilepsy, and epilepsy with chronic interictal psychosis", PSYCH RES-N, 108(1), 2001, pp. 1-15

Abstract

Chronic interictal psychotic syndromes, often resembling schizophrenia, develop in some patients with epilepsy. Although widespread brain abnormalities are recognized as characteristic of schizophrenia, prevailing but controversial hypotheses on the co-occurrence of epilepsy and psychosis implicateleft temporal lobe pathology. In this study, quantitative MRI methods wereused to address the regional specificity of structural brain abnormalitiesin patients with epilepsy plus chronic interictal psychosis (E + PSY, n = 9) relative to three comparison groups: unilateral temporal lobe epilepsy without chronic psychosis MLE, n = 18), schizophrenia (SCZ, n = 46), and healthy control subjects (HC, n = 57). Brain measures, derived from a coronal spin-echo MRI sequence, were adjusted for age and cerebral volume. Relativeto HC, all patient groups had ventricular enlargement and smaller temporallobe, frontoparietal, and superior temporal gyrus gray matter volumes, with the extent of these abnormalities greatest in E + PSY. Only TLE had temporal lobe white matter deficits, as well as smaller hippocampi, which were ipsilateral to the seizure focus. Structural brain abnormalities in E + PSY are not restricted to the left temporal lobe. The confluence of cortical gray matter deficits in E + PSY and SCZ suggests salience to chronic psychosis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 06/04/20 alle ore 05:41:33