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Titolo:
Possible induction of systemic lupus erythematosus by zonisamide
Autore:
Mutoh, K; Hidaka, Y; Hirose, Y; Kimura, M;
Indirizzi:
Shimada Municipal Hosp, Dept Pediat, Shimada 427, Japan Shimada Municipal Hosp Shimada Japan 427 Dept Pediat, Shimada 427, Japan Shizuoka Childrens Hosp, Dept Allergy & Clin Immunol, Shizuoka, Japan Shizuoka Childrens Hosp Shizuoka Japan & Clin Immunol, Shizuoka, Japan
Titolo Testata:
PEDIATRIC NEUROLOGY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 340 - 343
SICI:
0887-8994(200110)25:4<340:PIOSLE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LANDAU-KLEFFNER SYNDROME; DRUG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Mutoh, K Shimada Municipal Hosp, Dept Pediat, 1200-5 Noda, Shimada 427, Japan Shimada Municipal Hosp 1200-5 Noda Shimada Japan 427 427, Japan
Citazione:
K. Mutoh et al., "Possible induction of systemic lupus erythematosus by zonisamide", PED NEUROL, 25(4), 2001, pp. 340-343

Abstract

An epileptic male to whom zonisamide and ethosuximide had been administered exhibited fever, pericarditis, pleuritis, arthralgia, and elevated titersof antinuclear antibody and anti-DNA-antibody at 5 years, 11 months of age. It was suggested that zonisamide induced the systemic lupus erythematosussymptoms because the antinuclear antibody titers began to rise after zonisamide was administered, and clinical recovery and a decrease in the anti-DNA-antibody levels promptly followed the discontinuation of the drug. The positive lymphocyte transformation test results against zonisamide further supports the etiologic relationship of the male's lupus and the drug. This first case of zonisamide-induced lupus should alert physicians to the possibility of this serious unwanted effect in patients receiving zonisamide. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:33:25