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Titolo:
Renal hemodynamic effects of L-NAME during postnatal maturation in conscious lambs
Autore:
Sener, A; Smith, FG;
Indirizzi:
Univ Calgary, Fac Med, Dept Physiol & Biophys, Calgary, AB T2N 4N1, CanadaUniv Calgary Calgary AB Canada T2N 4N1 ophys, Calgary, AB T2N 4N1, Canada
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 11, volume: 16, anno: 2001,
pagine: 868 - 873
SICI:
0931-041X(200111)16:11<868:RHEOLD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ANGIOTENSIN-II; DEVELOPING PIGLET; INHIBITION; RESPONSES; KIDNEY; FUROSEMIDE; MODULATION; RELAXATION; TERM;
Keywords:
renal vascular resistance; renal blood flow; newborn sheep; renal vascular tone; nitric oxide; L-NAME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, FG Univ Calgary, Fac Med, Dept Physiol & Biophys, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada Univ Calgary 3330 Hosp Dr NW Calgary AB Canada T2N 4N1 1, Canada
Citazione:
A. Sener e F.G. Smith, "Renal hemodynamic effects of L-NAME during postnatal maturation in conscious lambs", PED NEPHROL, 16(11), 2001, pp. 868-873

Abstract

The purpose of the present study was to investigate the effects of the L-arginine analogue, N-G-nitro-L-arginine methyl ester, L-NAME, in modulating renal hemodynamics during postnatal maturation in conscious chronically instrumented lambs. To this end, renal hemodynamic responses to intravenous injection of 10, 20, and 40 mg/kg L-NAME, as well as its inactive enantiomer D-NAME, were measured for 4 h in conscious lambs approximately 1 week (n=10), 3 weeks (n=12), and 6 weeks (n=14) of age. Administration of L-NAME was associated with an increase in renal vascular resistance (RVR) leading to adecrease in renal blood flow. One-week-old lambs were more sensitive to the effects of L-NAME, a marked increase in RVR occurring after the smallest dose administered at 1 week but not at 3 and 6 weeks of age. Renal hemodynamic effects of L-NAME as well as the duration of the responses were also age dependent, such that changes in RVR were greatest and most prolonged in 1-week-old lambs. In addition, a smaller dose of L-NAME was required to attenuate acetylcholine-induced renal vasodilation in lambs aged 1 week compared with older animals. Our data provide new evidence to support the premise that endogenously produced nitric oxide plays a predominant role in regulating renal vascular tone early in life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:29:11