Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Positive skin and oral challenge responses to potato and occurrence of immunoglobulin E antibodies to patatin (Sol t 1) in infants with atopic dermatitis
Autore:
Majamaa, H; Seppala, U; Palosuo, T; Turjanmaa, K; Kalkkinen, N; Reunala, T;
Indirizzi:
Tampere Univ Hosp, Dept Dermatol, FIN-33521 Tampere, Finland Tampere Univ Hosp Tampere Finland FIN-33521 , FIN-33521 Tampere, Finland Univ Tampere, FIN-33101 Tampere, Finland Univ Tampere Tampere Finland FIN-33101 mpere, FIN-33101 Tampere, Finland Univ Helsinki, Inst Biotechnol, Helsinki, Finland Univ Helsinki HelsinkiFinland inki, Inst Biotechnol, Helsinki, Finland Natl Publ Hlth Inst, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland Publ Hlth Inst, Helsinki, Finland
Titolo Testata:
PEDIATRIC ALLERGY AND IMMUNOLOGY
fascicolo: 5, volume: 12, anno: 2001,
pagine: 283 - 288
SICI:
0905-6157(200110)12:5<283:PSAOCR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
EOSINOPHIL CATIONIC PROTEIN; FOOD ALLERGY; INTESTINAL INFLAMMATION; DIAGNOSTIC-ACCURACY; PATCH TESTS; RAW POTATO; CHILDREN; PRICK; HYPERSENSITIVITY; IGE;
Keywords:
allergen; atopic dermatitis; food allergy; IgE; infants; patatin; potato; Sol t 1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Majamaa, H Tampere Univ Hosp, Dept Dermatol, POB 2000, FIN-33521 Tampere, Finland Tampere Univ Hosp POB 2000 Tampere Finland FIN-33521 , Finland
Citazione:
H. Majamaa et al., "Positive skin and oral challenge responses to potato and occurrence of immunoglobulin E antibodies to patatin (Sol t 1) in infants with atopic dermatitis", PEDIAT A IM, 12(5), 2001, pp. 283-288

Abstract

The clinical significance and molecular specificity of hypersensitivity reactions to raw and cooked potatoes remain ambiguous. We therefore investigated the clinical hypersensitivity to raw and cooked potato in infants suspected to have potato allergy and compared the findings with the occurrence of immunoglobulin E (IgE) antibodies to patatin (Sol t 1), characterized as the primary allergen of potato. Twelve infants (10 to 24 months of age) suffering from atopic dermatitis (AD) and suspected to have adverse reactions to potato, were examined. As a skin exposure test we used rubbing with bothraw and cooked potato, and used open oral challenge with cooked potato for7 days. A special eczema scoring system (SCORAD) was used to assess the severity of symptoms and signs of AD. Skin-prick tests (SPTs) were performed with raw potato and natural Sol t 1, and serological studies included measurement of total serum IgE and IgE antibodies to Sol t 1, and potato radioallergosorbent testing (RAST). The skin-rubbing test with raw potato was positive in seven (58%) and the oral challenge positive in eight (67%) infants. One infant presented with an immediate reaction and seven with a delayed reaction, i.e. exacerbation of AD, after oral challenge responses to cooked potato. Nine (75%) infants had IgE antibodies to Sol t 1 in enzyme-linked immunosorbent assay (ELISA), and SPT to natural Sol t 1 was positive in six (50%) potato-allergic infants. In conclusion, we observed positive challenge responses to both raw and cooked potato in food-allergic atopic infants. The presence of IgE antibodies and concomitant positive SPTs to the heat-stable potato allergen, Sol t 1, suggest that cooked potato can be an allergenic food for infants suffering from AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:32:12