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Titolo:
NETWORK OF TUFTED LAYER-5 PYRAMIDAL NEURONS
Autore:
MARKRAM H;
Indirizzi:
WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL
Titolo Testata:
Cerebral cortex
fascicolo: 6, volume: 7, anno: 1997,
pagine: 523 - 533
SICI:
1047-3211(1997)7:6<523:NOTLPN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT VISUAL-CORTEX; LONG-TERM POTENTIATION; D-ASPARTATE RECEPTORS; SYNAPTIC TRANSMISSION; DENDRITIC MORPHOLOGY; NEOCORTICAL NEURONS; CENTRAL SYNAPSES; DEPRESSION; CONNECTIONS; PLASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
97
Recensione:
Indirizzi per estratti:
Citazione:
H. Markram, "NETWORK OF TUFTED LAYER-5 PYRAMIDAL NEURONS", Cerebral cortex, 7(6), 1997, pp. 523-533

Abstract

Tufted layer 5 (TL5) pyramidal neurons are important projection neurons from the cerebral cortex to subcortical areas. Recent and ongoing experiments aimed at understanding the computational analysis performedby a network of synaptically connected TL5 neurons are reviewed here. The experiments employed dual and triple whole-cell patch clamp recordings from visually identified and preselected neurons in brain slicesof somatosensory cortex of young (14- to 16-day-old) rats. These studies suggest that a local network of TL5 neurons within a cortical module of diameter 300 mu m consists of a few hundred neurons that are extensively interconnected with reciprocal feedback from at least first-,second- and third-order target neurons. A statistical analysis of synaptic innervation suggests that this recurrent network is not randomlyarranged and hence each neuron could be functionally unique. Synaptictransmission between these neurons is characterized by use-dependent synaptic depression which confers novel properties to this recurrent network of neurons. First, a range of rates of depression for differentsynaptic connections enable each TL5 neuron to receive a unique mixture of information about the average firing rates and the temporally correlated action potential (AP) activity in the population of presynaptic TL5 neurons. Second, each AP generated by any neuron in the networkinduces a change (defined as an iteration step) in the functional coupling of the neurons in the network (defined as network configuration). It is proposed that the network configuration is iterated during a stimulus to achieve an optimally orchestrated network response. Hebbian, anti-Hebbian and neuromodulatory-induced modifications of neurotransmitter release probability change the rates of synaptic depression andthereby alter the iteration step size. These data may be important tounderstand the dynamics of electrical activity within the network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:12:35