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Titolo:
A new splicing variant for human tyrosine hydroxylase in the adrenal medulla
Autore:
Ohye, T; Ichinose, H; Yoshizawa, T; Kanazawa, I; Nagatsu, T;
Indirizzi:
Fujita Hlth Univ, Inst Comprehens Med Sci, Aichi 4701192, Japan Fujita Hlth Univ Aichi Japan 4701192 ehens Med Sci, Aichi 4701192, Japan Univ Tsukuba, Inst Clin Med, Dept Neurol, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tokyo, Grad Sch Med, Dept Neurol, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 ch Med, Dept Neurol, Tokyo 1138655, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 312, anno: 2001,
pagine: 157 - 160
SICI:
0304-3940(20011026)312:3<157:ANSVFH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; MESSENGER-RNA; SINGLE GENE;
Keywords:
tyrosine hydroxylase; splicing variant; human; adrenal medulla; brain; progressive supranuclear palsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Nagatsu, T Fujita Hlth Univ, Inst Comprehens Med Sci, Aichi 4701192, JapanFujita Hlth Univ Aichi Japan 4701192 ci, Aichi 4701192, Japan
Citazione:
T. Ohye et al., "A new splicing variant for human tyrosine hydroxylase in the adrenal medulla", NEUROSCI L, 312(3), 2001, pp. 157-160

Abstract

It has been reported that several mRNA isoforms of tyrosine 3-monooxygenase (tyrosine hydroxylase; TH) occur only in primates. New TH isoforms produced by skipping of exon 3 in the adrenal medulla of patients with progressive supranuclear palsy (PSP) have recently been reported, J. Neurochem. 67 (1996) 19. Here, we looked for the presence of new TH isoforms in control brains and adrenal medulla and in brains from patients with PSP. We found a novel type of TH mRNA in the adrenal medulla from one of the control subjects. The mRNA lacked exon 4, resulting in a premature stop codon at amino acid147. This result suggests the importance of alternative splicing in the regulation of TH activity. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 22:01:42