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Titolo:
Hypothalamic-pituitary-adrenal axis dysregulation in depersonalization disorder
Autore:
Simeon, D; Guralnik, O; Knutelska, M; Hollander, E; Schmeidler, J;
Indirizzi:
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA Mt Sinai Sch Med New York NY USA 10029 t Psychiat, New York, NY 10029 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 793 - 795
SICI:
0893-133X(200111)25:5<793:HADIDD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; DISSOCIATION; SCALE; ABUSE; WOMEN;
Keywords:
dissociation; depersonalization; dexamethasone; suppression; HPA axis; cortisol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Simeon, D Mt Sinai Sch Med, Dept Psychiat, 1 Gustave L Levy Pl,Psychiat Box 1229, New York, NY 10029 USA Mt Sinai Sch Med 1 Gustave L Levy Pl,Psychiat Box 1229 New York NY USA 10029
Citazione:
D. Simeon et al., "Hypothalamic-pituitary-adrenal axis dysregulation in depersonalization disorder", NEUROPSYCH, 25(5), 2001, pp. 793-795

Abstract

Background: The purpose of this preliminary study was to investigate HPA axis function in dissociation. Methods: Nine subjects with DSM-IV depersonalization disorder (DPD), without lifetime Posttraumatic Stress Disorder (PTSD) or current major depression, were compared to nine healthy comparison (HC) subjects of comparable age and gender. Results: DPD subjects demonstrated significant hyposuppression to low-dose dexamethasone administration and significantly elevated morning plasma cortisol levels when covaried-for depression scores, but no difference in 24-hour urinary cortisol excretion. Dissociation scores powerfully predicted suppression whereas depression scores did not contribute to the prediction. Conclusions: Primary dissociative conditions, such as depersonalization disorder, may be associated with a pattern of HPA axis dysregulation that differs from PTSD and merits further study. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:49:55