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Titolo:
Effects of triazolam on brain activity during episodic memory encoding: A PET study
Autore:
Mintzer, MZ; Griffiths, RR; Contoreggi, C; Kimes, AS; London, ED; Ernst, M;
Indirizzi:
Johns Hopkins Univ, Sch Med, Behav Biol Res Ctr, Dept Psychiat & Behav Sci, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 av Sci, Baltimore, MD 21224 USA Natl Inst Drug Abuse, Intramural Res Program, Baltimore, MD USA Natl Inst Drug Abuse Baltimore MD USA ral Res Program, Baltimore, MD USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 744 - 756
SICI:
0893-133X(200111)25:5<744:EOTOBA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; MEDIAL TEMPORAL-LOBE; BENZODIAZEPINE RECEPTORS; SUSTAINED ATTENTION; ANTERIOR CINGULATE; INDUCED AMNESIA; FRONTAL-CORTEX; LONG-TERM; ACTIVATION; RETRIEVAL;
Keywords:
triazolam; benzodiazepines; episodic memory; encoding; positron emission tomography; regional cerebral blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Mintzer, MZ Johns Hopkins Univ, Sch Med, Behav Biol Res Ctr, Dept Psychiat& Behav Sci, 5510 Nathan Shock Dr, Baltimore, MD 21224 USA Johns Hopkins Univ 5510 Nathan Shock Dr Baltimore MD USA 21224
Citazione:
M.Z. Mintzer et al., "Effects of triazolam on brain activity during episodic memory encoding: A PET study", NEUROPSYCH, 25(5), 2001, pp. 744-756

Abstract

It is well documented that acute administration of the benzodiazepine hypnotic drug triazolam (Halcion (R)) impairs episodic memory encoding. We examined the neuroanatomical substrates of this effect in healthy adult volunteers using a double-blind, within-subject design. Following oral capsule administration (0.25 mg/70 kg triazolam or placebo), regional cerebral bloodflow (rCBF) was measured using positron emission tomography (PET) with O-15-H2O during the performance of semantic categorization, orthographic categorization, and visual fixation (resting) tasks. rCBF associated with episodic memory encoding was measured by the difference in rCBF during the orthographic categorization task relative to that during the semantic categorizationtask. Results in the placebo condition (n = 9) replicated those of previous nonpharmacological encoding studies (activation in the left prefrontal cortex, cerebellum, anterior cingulate cortex, temporal cortex, and occipitalcortex). Relative to placebo, results in the triazolam condition (n = 6) revealed significantly impaired memory performance, and deactivation during encoding in a subset of areas shown previously to be associated with encoding (anterior cingulate cortex, cerebellum, and precuneus). Results are discussed in relation to triazolam's effects on mnemonic versus attentional processes. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:53:44