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Titolo:
Behavioral profile of CCK2 receptor-deficient mice
Autore:
Dauge, V; Sebret, A; Beslot, F; Matsui, T; Roques, BP;
Indirizzi:
UFR Sci Pharmaceut & Biol, CNRS,U226, INSERM,UMR 8600, Dept Pharmacochim Mol & Struct,, F-75270 Paris 06, France UFR Sci Pharmaceut & Biol Paris France 06 uct,, F-75270 Paris 06, France Kobe Univ, Sch Med, Dept Med, Div 3, Kobe, Hyogo, Japan Kobe Univ Kobe Hyogo Japan Sch Med, Dept Med, Div 3, Kobe, Hyogo, Japan
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 690 - 698
SICI:
0893-133X(200111)25:5<690:BPOCRM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ BINDING-SITES; RAT CEREBRAL-CORTEX; GUINEA-PIG BRAIN; NUCLEUS-ACCUMBENS; KNOCKOUT MICE; LOCOMOTOR-ACTIVITY; PLUS-MAZE; ANTAGONISTS; ANXIETY; DOPAMINE;
Keywords:
CCK2 receptor-deficient mice; memory; anxiety; motor activity; neuromuscular;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Dauge, V UFR Sci Pharmaceut & Biol, CNRS,U226, INSERM,UMR 8600, Dept Pharmacochim Mol & Struct,, 4 Ave Observ, F-75270 Paris 06, France UFR Sci Pharmaceut & Biol 4 Ave Observ Paris France 06 6, France
Citazione:
V. Dauge et al., "Behavioral profile of CCK2 receptor-deficient mice", NEUROPSYCH, 25(5), 2001, pp. 690-698

Abstract

CCK2 receptor-deficient mice were used to investigate in vivo the role of this receptor in behavior. Mutant mice showed a neuromuscular impairment inthe traction and rotarod tests but not in the chimney test. Brain cholecystokinin has been shown to participate in stress-related behaviors. However,CCK2 receptor-deficient mice did not show behavioral modifications compared to wild-type mice in the elevated plus maze and in the motility conditioned suppression test, indicating that compensatory mechanisms very likely occur following CCK2 receptor invalidation. On the other hand, a hyperlocomotor activity was observed in actimeter which can be related to an impairmentin environmental habituation. Finally, CCK2 receptor-deficient mice showedan impairment of performance in the spontaneous alternation behavior as expected from the opposite effects evoked by CCK2 agonists, supporting the physiological role of CCK2 receptors in attention and/or memory processes. This result is reinforced by the defects observed in these functions after the administration of CCK2 antagonists. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 01/04/20 alle ore 01:41:32