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Titolo:
Effects of endogenous neurotransmitters on the in vivo binding of dopamineand 5-HT radiotracers in mice
Autore:
Rice, OV; Gatley, SJ; Shen, J; Huemmer, CL; Rogoz, R; DeJesus, OT; Volkow, ND; Gifford, AN;
Indirizzi:
Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 Lab, Dept Med, Upton, NY 11973 USA Univ Wisconsin, Dept Med Phys, Sch Med, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Phys, Sch Med, Madison, WI 53706 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 679 - 689
SICI:
0893-133X(200111)25:5<679:EOENOT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; NON-BENZAZEPINE ANTAGONIST; H-3 N-METHYLSPIPERONE; IN-VIVO; RAT-BRAIN; RECEPTOR ANTAGONIST; INVIVO BINDING; KINETIC-PROPERTIES; D-2 RECEPTORS; HIGH-AFFINITY;
Keywords:
positron emission tomography; dopamine; serotonin; 5-HT receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Gifford, AN Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 d, Upton, NY 11973 USA
Citazione:
O.V. Rice et al., "Effects of endogenous neurotransmitters on the in vivo binding of dopamineand 5-HT radiotracers in mice", NEUROPSYCH, 25(5), 2001, pp. 679-689

Abstract

Several studies have indicated that the in vivo binding of D, receptor positron emission tomography radiotracers can, tinder some conditions, be influenced by competition with endogenous dopamine. The present study was undertaken to compare the extent to which the in vivo binding in mice of radiotracers to other amine neuroreceptors, namely D-1, 5-HT2A and 5-HT1A receptors, can also be modulated by neurotransmitter competition. For dopamine radiotracers we examined [H-3]raclopride as a D-2 radiotracer and [H-3]A69024 as a D-1 radiotracer. Striatal binding of both radiotracers was substantially reduced by administration of the dopamine releaser, amphetamine, althoughonly at a high dose. [H-3]raclopride was decreased more than [H-3]A69024. Dopamine depletion with 4-hydroxybutyrate strongly increased [H-3]raclopride binding but failed to increase [H-3]A69024 binding. For 5-HT radiotracerswe examined [H-3]-methylspiperone as a 5-HT2A radiotracer and [H-3]WAY 100635 as a 5-HT1A radiotracer. Cortical binding of both radiotracers was unaffected by the 5-HT releaser, p-chloroamphetamine. [H-3]WAY 100635 binding was additionally unaffected by 5-HT release with fenfluramine and by 5-HT depletion with p-chlorophenylalanine. In conclusion, of the four radiotracersexamined, [H-3]raclopride binding to D-2 receptors had greatest sensitivity to changes in endogenous neurotransmitter levels. [H-3]A69024 binding to D-2 receptors was affected only by neurotransmitter increases. [H-3]N-methylspiperone binding to 5-HT2A receptors and [H-3]WAY 100635 binding to 5-HT1A receptors appeared insensitive to changes in neurotransmitter levels. (C)2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:54:19