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Titolo:
Enhanced reactivity and vulnerability to cocaine following methylphenidatetreatment in adolescent rats
Autore:
Brandon, CL; Marinelli, M; Baker, LK; White, FJ;
Indirizzi:
Finch Univ Hlth Sci Chicago Med Sch, Dept Cellular & Mol Pharmacol, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch N Chicago IL USA 60064 , IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch, Dept Cell Biol & Anat, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch N Chicago IL USA 60064 , IL 60064 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 651 - 661
SICI:
0893-133X(200111)25:5<651:ERAVTC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SUBSTANCE USE DISORDERS; BEHAVIORAL SENSITIZATION; LOCOMOTOR-ACTIVITY; EXTRACELLULAR DOPAMINE; ORAL METHYLPHENIDATE; MOLECULAR MECHANISMS; NUCLEUS-ACCUMBENS; PREWEANLING RATS;
Keywords:
attention deficit hyperactivity disorder; self-administration; sensitization; Ritalin (R); substance abuse disorder; addiction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: White, FJ Finch Univ Hlth Sci Chicago Med Sch, Dept Cellular & Mol Pharmacol, 3333 Green Bay Rd, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch 3333 Green Bay Rd N Chicago IL USA 60064
Citazione:
C.L. Brandon et al., "Enhanced reactivity and vulnerability to cocaine following methylphenidatetreatment in adolescent rats", NEUROPSYCH, 25(5), 2001, pp. 651-661

Abstract

Treatment of attention deficit hyperactivity disorder with the psychostimulant drug methylphenidate (MP) has increased dramatically among schoolchildren. We tested whether repeated exposure to moderate doses of MP (5 and 10 mg/kg IP for 5 or 7 days) in adolescent rats increased reactivity to cocaine measured by motor responses (ambulations and rearing) to a cocaine challenge in adulthood. We later tested whether repeated exposure to a low dose of MP (2 mg/kg IP for 7 days) enhanced the psychomotor effects of cocaine, measured by different challenge doses (0-30 mg/kg) as well as to the reinforcing effects of cocaine, measured by self-administration of low-dose infusion (75 mug/kg, IV). We found that exposure to moderate doses of MP enhancedpsychomotor responses to cocaine but exposure to a low dose only increasedcocaine self-administration. These results suggest that adolescent exposure to low doses of MP in rats may increase the incentive value of low reinforcers, thereby rendering adult rats more susceptible to cocaine self-administration. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 13:05:21