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Titolo:
Role of dopamine D-4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats
Autore:
Zhang, KH; Tarazi, FI; Baldessarini, RJ;
Indirizzi:
Massachusetts Gen Hosp, McLean Div, Mailman Res Ctr, Belmont, MA 02478 USAMassachusetts Gen Hosp Belmont MA USA 02478 es Ctr, Belmont, MA 02478 USA Harvard Univ, Sch Med, Consolidated Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ated Dept Psychiat, Boston, MA 02115 USA Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 , Program Neurosci, Boston, MA 02115 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 624 - 632
SICI:
0893-133X(200111)25:5<624:RODDRI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENTION-DEFICIT DISORDER; PREFRONTAL CORTEX; DRD4 GENE; BIOCHEMICAL-EVIDENCE; EXCITOTOXIC LESIONS; D-4-LIKE RECEPTORS; LOCOMOTOR-ACTIVITY; NUCLEUS-ACCUMBENS; NOVELTY SEEKING; PRIMATE BRAIN;
Keywords:
attention deficit-hyperactivity disorder; autoradiography; dopamine; D-4; 6-hydroxydopamine; motor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, KH McLean Hosp, Mailman Res Ctr, 115 Mill St, Belmont, MA 02478 USAMcLean Hosp 115 Mill St Belmont MA USA 02478 lmont, MA 02478 USA
Citazione:
K.H. Zhang et al., "Role of dopamine D-4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats", NEUROPSYCH, 25(5), 2001, pp. 624-632

Abstract

The role of dopamine D-4 receptors in behavioral hyperactivity was investigated by assessing D-4 receptor expression in brain regions and behavioral effects of D-4 receptor-selective ligands in juvenile rats with neonatal 6-hydroxydopamine lesions, a laboratory model for attention deficit-hyperactivity disorder (ADHD). Autoradiographic analysis indicated that motor hyperactivity in lesioned rats was closely correlated with increases in D-4 but not D-2 receptor levels in caudate-putamen. D-4-selective antagonist CP-293,019 dose-dependently reversed lesion-induced hyperactivity, and D-4-agonistCP-226,269 increased it. These results indicate a physiological role of dopamine D-4 receptors in motor behavior, and may suggest much-needed innovative treatments for ADHD. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:11:19