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Titolo:
Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys
Autore:
Zhang, ZM; Andersen, A; Grondin, R; Barber, T; Avison, R; Gerhardt, G; Gash, D;
Indirizzi:
Univ Kentucky, Coll Med, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 & Neurobiol, Lexington, KY 40536 USA Univ Kentucky, Coll Med, Morris K Udall Parkinsons Dis Res Ctr Excellence,Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 r Excellence,Lexington, KY 40536 USA Univ Kentucky, Coll Med, Magnet Resonance Imaging & Spect Ctr, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 & Spect Ctr, Lexington, KY 40536 USA
Titolo Testata:
NEUROIMAGE
fascicolo: 5, volume: 14, anno: 2001,
pagine: 1159 - 1167
SICI:
1053-8119(200111)14:5<1159:PMMOAC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOBUS-PALLIDUS NEURONS; BRAIN DOPAMINE ACTIVITY; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; FUNCTIONAL MRI; PARS COMPACTA; APOMORPHINE; DECLINE; PATHOPHYSIOLOGY; IMPAIRMENT;
Keywords:
putamen; caudate nucleus; globus pallidus externa; globus pallidus interna; substantia nigra; aging; apomorphine; amphetamine; MRI; rhesus monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, ZM Univ Kentucky, Coll Med, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 l, Lexington, KY 40536 USA
Citazione:
Z.M. Zhang et al., "Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys", NEUROIMAGE, 14(5), 2001, pp. 1159-1167

Abstract

While the pathophysiological changes induced by the loss of dopamine innervation in the basal ganglia by Parkinson's disease (PD) are well studied, little is, known about functional changes in the neural circuitry of this area during normal aging. Here we report the first survey of age-associated changes in the basal ganglia of behaviorally characterized, awake rhesus monkeys, using pharmacological MRI to map responses to dopaminergic stimulation. Apomorphine, a mixed D-1/D-2 dopamine receptor agonist, evoked little change in the substantia nigra (SN) of aged animals while significantly reducing activation in young adult I monkeys. Compared to young animals, both apomorphine and D-amphetamine (which increases synaptic dopamine levels) significantly increased activation of the aged rhesus globus pallidus externa (GPe). In addition, the aged animals showed decreased activity in the putamen in response to D-amphetamine administration. Although the responses in the SN and putamen of the aged monkeys differed from those in animal models of PD, the apomorphine-evoked activation i of their GPe corresponded with apomorphine-induced increases in neuronal activity seen in Parkinson's patients and animal models. Given the major role of the GPe in regulating motor behavior, the altered responses in the aged GPe may contribute significantlyto the motor slowing and movement dysfunctions characterizing advanced age. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:52:04