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Titolo:
Arousal dissociates amygdala and hippocampal fear responses: Evidence fromsimultaneous fMRI and skin conductance recording
Autore:
Williams, LM; Phillips, ML; Brammer, MJ; Skerrett, D; Lagopoulos, J; Rennie, C; Bahramali, H; Olivieri, G; David, AS; Peduto, A; Gordon, E;
Indirizzi:
Westmead Hosp, Brain Dynam Ctr, Westmead, NSW 2145, Australia Westmead Hosp Westmead NSW Australia 2145 , Westmead, NSW 2145, Australia Westmead Hosp, Dept Med Phys Nucl Med & Ultrasound, Westmead, NSW 2145, Australia Westmead Hosp Westmead NSW Australia 2145 , Westmead, NSW 2145, Australia Westmead Hosp, Dept Radiol, MRI Unit, Westmead, NSW 2145, Australia Westmead Hosp Westmead NSW Australia 2145 , Westmead, NSW 2145, Australia Univ Sydney, Dept Psychol, Sydney, NSW 2006, Australia Univ Sydney SydneyNSW Australia 2006 sychol, Sydney, NSW 2006, Australia Univ Sydney, Sch Phys, Sydney, NSW 2006, Australia Univ Sydney Sydney NSWAustralia 2006 h Phys, Sydney, NSW 2006, Australia Univ Sydney, Dept Psychol Med, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ol Med, Sydney, NSW 2006, Australia Inst Psychiat, London SE5 8AZ, England Inst Psychiat London England SE5 8AZ t Psychiat, London SE5 8AZ, England
Titolo Testata:
NEUROIMAGE
fascicolo: 5, volume: 14, anno: 2001,
pagine: 1070 - 1079
SICI:
1053-8119(200111)14:5<1070:ADAAHF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFERENTIAL NEURAL RESPONSE; EMOTIONAL FACIAL EXPRESSIONS; CORTEX; BRAIN; KNOWLEDGE; CINGULATE; SYSTEMS; DISGUST;
Keywords:
fMRI; amygdala; hippocampus; arousal; fear; facial emotion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, LM Westmead Hosp, Brain Dynam Ctr, Westmead, NSW 2145, AustraliaWestmead Hosp Westmead NSW Australia 2145 SW 2145, Australia
Citazione:
L.M. Williams et al., "Arousal dissociates amygdala and hippocampal fear responses: Evidence fromsimultaneous fMRI and skin conductance recording", NEUROIMAGE, 14(5), 2001, pp. 1070-1079

Abstract

The experience and appraisal of threat is essential to human and animal survival. Lesion evidence suggests that the subjective experience of fear relies upon amygdala-medial frontal activity (as well as autonomic arousal), whereas the factual context of threat stimuli depends upon hippocampal-lateral frontal activity. This amygdala-hippocampus dissociation has not previously been demonstrated in vivo. To explore this differentiation, we employedfunctional magnetic resonance imaging (fMRI) and simultaneous skin conductance response (SCR) measures of phasic arousal, while subjects viewed fearful versus neutral faces. fMRI activity was subaveraged according to whetheror not the subject evoked an arousal SCR to each discrete face stimulus. The fMRI-with arousal and fMRI- without arousal data provided a distinct differentiation of amygdala and hippocampal networks. Amygdala-medial frontal activity was observed only with SCRs, whereas hippocampus-lateral frontal activity occurred only in the absence of SCRs. The findings provide direct evidence for a dissociation between human amygdala and hippocampus networks in the visceral experience versus declarative fact processing of fear. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:29:05