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Titolo:
Metabotropic glutamate receptors stimulate phospholipase D via different pathways in the adult and neonate rat hippocampus
Autore:
Attucci, S; Albani-Torregrossa, S; Moroni, F; Pellegrini-Giampietro, DE;
Indirizzi:
Univ Florence, Dipartimento Farmacol Preclin & Clin, I-50139 Florence, Italy Univ Florence Florence Italy I-50139 lin & Clin, I-50139 Florence, Italy
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 10, volume: 26, anno: 2001,
pagine: 1151 - 1155
SICI:
0364-3190(200110)26:10<1151:MGRSPD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; ACTIVATION; SLICES; BRAIN; ACID; AGONIST;
Keywords:
metabotropic glutamate receptors; phospholipase D; ontogeny; PCCG-13; rat hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Pellegrini-Giampietro, DE Univ Florence, Dipartimento Farmacol Preclin & Clin, Viale Pieraccini 6, I-50139 Florence, Italy Univ Florence Viale Pieraccini 6 Florence Italy I-50139
Citazione:
S. Attucci et al., "Metabotropic glutamate receptors stimulate phospholipase D via different pathways in the adult and neonate rat hippocampus", NEUROCHEM R, 26(10), 2001, pp. 1151-1155

Abstract

In order to characterize the ontogenetic profile of metabotropic glutamate(mGlu) receptors coupled to phospholipase D (PLD) we examined the effects of selected mGlu agents on PLD activity in immature and adult rat hippocampus. The group I mGlu receptor agonist 3,5-dihydroxyphenylglycine stimulatedPLD in immature tissue, but reduced the PLD response evoked by the nonselective mGlu receptor agonist (1S,3R)-1-an-aminocyclopentane-1,3-dicarboxylate [(1S,3R)-ACPD] in adult hippocampus. (2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl) glycine (PCCG-13), a recently characterized selective antagonist of PLD-coupled mGlu receptors, displayed a much greater activity in reducing the PLD response to (1S,3R)-ACPD in adult than in neonate hippocampus. Our results lend support to the hypothesis that glutamatergic activation of PLD in the rat hippocampus is developmentally regulated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:43:55