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Titolo:
From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
Autore:
Cleveland, DW; Rothstein, JD;
Indirizzi:
Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 nc Res, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21288 USA Johns Hopkins Univ Baltimore MD USA 21288 ch Med, Baltimore, MD 21288 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 11, volume: 2, anno: 2001,
pagine: 806 - 819
SICI:
1471-0048(200111)2:11<806:FCTLGD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; CU/ZN-SUPEROXIDE-DISMUTASE; TRANSGENIC MOUSE MODEL; LINKED SUPEROXIDE-DISMUTASE-1 MUTANT; THYROTROPIN-RELEASING-HORMONE; HEAVY NEUROFILAMENT SUBUNIT; GLUTAMATE TRANSPORTER EAAT2; PLACEBO-CONTROLLED TRIAL; BLIND CONTROLLED TRIAL; NITRIC-OXIDE SYNTHASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
157
Recensione:
Indirizzi per estratti:
Indirizzo: Cleveland, DW Univ Calif San Diego, Ludwig Inst Canc Res, 9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 SA
Citazione:
D.W. Cleveland e J.D. Rothstein, "From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS", NAT REV NEU, 2(11), 2001, pp. 806-819

Abstract

Since its description by Charcot more than 130 years ago, the mechanism underlying the characteristic selective degeneration and death of motor neurons in amyotrophic lateral sclerosis has remained a mystery. Modern geneticshas now identified mutations in two genes - SOD1 and ALS2 - as primary causes of the disease, and has implicated others as potential contributors. Insights into these abnormalities, together with errors in the handling of synaptic glutamate and the potential excitotoxic response that this alteration provokes, have provided leads for the development of new strategies to identify an as yet elusive remedy for this progressive, fatal disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:21:36