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Titolo:
Induction, assembly, maturation and maintenance of a postsynaptic apparatus
Autore:
Sanes, JR; Lichtman, JW;
Indirizzi:
Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 11, volume: 2, anno: 2001,
pagine: 791 - 805
SICI:
1471-0048(200111)2:11<791:IAMAMO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTOR CLUSTERS; CULTURED MUSCLE-CELLS; TYROSINE KINASE MUSK; DEVELOPING NEUROMUSCULAR-JUNCTION; DUCHENNE MUSCULAR-DYSTROPHY; NEWLY FORMED SYNAPSES; EPSILON-SUBUNIT GENE; MUTANT MICE LACKING; SKELETAL-MUSCLE; IN-VIVO;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
169
Recensione:
Indirizzi per estratti:
Indirizzo: Sanes, JR Washington Univ, Sch Med, Dept Anat & Neurobiol, 660 S Euclid,Campus Box 8108, St Louis, MO 63110 USA Washington Univ 660 S Euclid,Campus Box 8108 St Louis MO USA 63110
Citazione:
J.R. Sanes e J.W. Lichtman, "Induction, assembly, maturation and maintenance of a postsynaptic apparatus", NAT REV NEU, 2(11), 2001, pp. 791-805

Abstract

The postsynaptic apparatus of the skeletal neuromuscular junction, like that of other synapses, contains a high-density patch of neurotransmitter receptors that Is closely associated with a variety of extracellular, transmembrane and cytoplasmic proteins that have adhesive, structural and signalling roles. The postsynaptic apparatus is organized by signals from the presynaptic nerve terminal. It changes in shape, size and molecular architecture as it matures. Once mature, it can be maintained for the life of the organism, but has the capacity for remodelling in response to altered Input. The molecular and cellular mechanisms that govern each of these stages are now being elucidated by a combination of microscopic and genetic methods, allowing the neuromuscular junction to serve as a model for smaller and less-accessible central synapses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:30:27