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Titolo:
Commuting the death sentence: How oocytes strive to survive
Autore:
Tilly, JL;
Indirizzi:
Harvard Univ, Massachusetts Gen Hosp, Sch Med,Vincent Ctr Reprod Biol, Dept Obstet & Gynecol, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 t Obstet & Gynecol, Boston, MA 02114 USA
Titolo Testata:
NATURE REVIEWS MOLECULAR CELL BIOLOGY
fascicolo: 11, volume: 2, anno: 2001,
pagine: 838 - 848
SICI:
1471-0072(200111)2:11<838:CTDSHO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; ARYL-HYDROCARBON RECEPTOR; EMBRYO IMPLANTATION RATE; IN-VITRO FERTILIZATION; CURRENT PERSPECTIVES; FOLLICULAR ATRESIA; CIGARETTE-SMOKING; OVARIAN TOXICITY; IMMUNE-SYSTEM; ADVANCED AGE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Tilly, JL Harvard Univ, Massachusetts Gen Hosp, Sch Med,Vincent Ctr ReprodBiol, Dept Obstet & Gynecol, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 Gynecol, Boston, MA 02114 USA
Citazione:
J.L. Tilly, "Commuting the death sentence: How oocytes strive to survive", NAT REV MOL, 2(11), 2001, pp. 838-848

Abstract

Programmed cell death claims up to 99.9% of the cells in the mammalian female germ line, which eventually drives irreversible infertility and ovarianfailure - the menopause in humans. New insights into the mechanisms that underlie germ-cell apoptosis have been provided by the study of oocyte deathin lower organisms and in genetically manipulated mice that lack apoptosis-regulatory proteins. With new therapeutic tools to control fertility, oocyte quality and ovarian lifespan on the horizon, understanding how and why the female body creates, only to delete, so many germ cells is imperative.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:21:25