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Titolo:
Transmembrane extracellular matrix-cytoskeleton crosstalk
Autore:
Geiger, B; Bershadsky, A; Pankov, R; Yamada, KM;
Indirizzi:
Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 Biol, IL-76100 Rehovot, Israel Natl Inst Craniofacial & Dent Res, Craniofacial Dev Biol & Regenerat Branch, NIH, Bethesda, MD 20892 USA Natl Inst Craniofacial & Dent Res Bethesda MD USA 20892 sda, MD 20892 USA
Titolo Testata:
NATURE REVIEWS MOLECULAR CELL BIOLOGY
fascicolo: 11, volume: 2, anno: 2001,
pagine: 793 - 805
SICI:
1471-0072(200111)2:11<793:TEMC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; FIBRONECTIN TYPE-III; ACTIN STRESS FIBERS; CELL-ADHESION; TYROSINE PHOSPHORYLATION; C-SRC; INTERFERENCE REFLECTION; CULTURED FIBROBLASTS; OSTEOCLAST FUNCTION; SUBSTRATE CONTACT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Geiger, B Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 6100 Rehovot, Israel
Citazione:
B. Geiger et al., "Transmembrane extracellular matrix-cytoskeleton crosstalk", NAT REV MOL, 2(11), 2001, pp. 793-805

Abstract

Integrin-mediated cell adhesions provide dynamic, bidirectional links between the extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and morphogenesis, focal adhesions and related structures convey information across the cell membrane, to regulate extracellular-matrix assembly, cell proliferation, differentiation, and death. This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:34:01